Notre Dame vs. Louisville Prediction, Odds, Picks - September 28, 2024

Updated Sep. 28, 2024 3:11 p.m. ET

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The No. 16 Notre Dame Fighting Irish (3-1) are less than a touchdown favorite (-6.5) on Saturday, September 28, 2024 against the No. 15 Louisville Cardinals (3-0). The point total is 45.5.

The Fighting Irish's last game was against the Miami (OH) RedHawks, and they won by a score of 28-3. In their last game, the Cardinals won versus the Georgia Tech Yellow Jackets, 31-19.

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Notre Dame vs. Louisville Game Information & Odds

When: Saturday, September 28, 2024 at 3:30 p.m. ET
Location: Notre Dame Stadium in South Bend, Indiana
TV: Peacock
Live Box Score on FOX Sports

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Notre Dame vs Louisville Betting Information updated as of September 28, 2024, 2:47 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-6.5 (-112)	-243	+196	45.5	-109	-111

Notre Dame vs. Louisville Prediction

Pick ATS: Louisville (+6.5)
Pick OU: Over (45.5)
Prediction: Notre Dame 26, Louisville 24

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the Louisville Cardinals game on FOX Sports!

Notre Dame vs. Louisville Betting Insights

Based on the spread and over/under, the implied score for the game is Fighting Irish 26, Cardinals 20.
The Fighting Irish have a 70.8% chance to collect the win in this meeting based on the moneyline's implied probability. The Cardinals hold a 33.8% implied probability.
Notre Dame has a record of 2-2-0 against the spread this season.
Louisville has won two games against the spread this year.

Notre Dame vs. Louisville: 2024 Stats Comparison

	Notre Dame	Louisville
Off. Points per Game (Rank)	32.8 (41)	47.3 (28)
Def. Points per Game (Rank)	9.8 (10)	11 (8)
Turnovers Allowed (Rank)	4 (51)	0 (1)
Turnovers Forced (Rank)	6 (41)	4 (74)

Notre Dame 2024 Key Players

Name	Position	Stats
Riley Leonard	QB	587 YDS (63.1%) / 1 TD / 2 INT 322 RUSH YDS / 6 RUSH TD / 80.5 RUSH YPG
Jeremiyah Love	RB	339 YDS / 4 TD / 84.8 YPG / 7.4 YPC
Jadarian Price	RB	193 YDS / 2 TD / 48.3 YPG / 7.4 YPC
Beaux Collins	WR	16 REC / 176 YDS / 1 TD / 44 YPG
Boubacar Traore	DL	10 TKL / 4 TFL / 3 SACK / 1 INT
Xavier Watts	DB	13 TKL / 0 TFL / 1 INT / 1 PD
Drayk Bowen	LB	13 TKL / 1 TFL / 1 SACK
Jack Kiser	LB	20 TKL / 0 TFL

Louisville 2024 Key Players

Name	Position	Stats
Tyler Shough	QB	850 YDS (68.4%) / 8 TD / 0 INT
Ja'Corey Brooks	WR	17 REC / 297 YDS / 2 TD / 99 YPG
Chris Bell	WR	6 REC / 167 YDS / 2 TD / 55.7 YPG
Keyjuan Brown	RB	126 YDS / 2 TD / 42 YPG / 6.6 YPC 3 REC / 34 REC YDS / 0 REC TD / 11.3 REC YPG
Tramel Logan	DL	3 TKL / 2 TFL / 3 SACK
Jared Dawson	DL	6 TKL / 3 TFL / 2 SACK
Tamarion McDonald	DB	4 TKL / 3 TFL / 2 SACK
Quincy Riley	DB	2 TKL / 0 TFL / 1 INT / 1 PD