Notre Dame vs. Louisville Prediction, Odds, Picks - October 7

Updated Oct. 7, 2023 3:06 p.m. ET

Data Skrive

The No. 25 Louisville Cardinals (5-0) and the 16th-ranked pass offense will play the No. 10 Notre Dame Fighting Irish (5-1) and the fourth-ranked passing defense on Saturday, October 7, 2023. The Fighting Irish are favored by 6.5 points in the outing. The over/under is set at 53.5.

The Fighting Irish's most recent contest was against the Duke Blue Devils, and they won by a score of 21-14. Against the NC State Wolfpack in their most recent contest, the Cardinals won 13-10.

Notre Dame vs. Louisville Game Information & Odds

When: Saturday, October 7, 2023 at 7:30 PM ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ABC
Live boxscore on FOX Sports

Notre Dame vs Louisville Betting Information updated as of October 7, 2023, 2:46 PM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-6.5 (-110)	-256	+207	53.5	-110	-110

Notre Dame vs. Louisville Prediction

Pick ATS: Notre Dame (-6.5)
Pick OU: Under (53.5)
Prediction: Notre Dame 30, Louisville 21

Learn more about the Notre Dame Fighting Irish vs. the Louisville Cardinals game on FOX Sports!

Notre Dame vs. Louisville Betting Insights

Based on the spread and over/under, the implied score for the game is Fighting Irish 30, Cardinals 24.
The Fighting Irish have a 71.9% chance to claim victory in this contest based on the moneyline's implied probability. The Cardinals have a 32.6% implied probability.
Notre Dame has won four games against the spread this season, while failing to cover or pushing twice.
Louisville has a record of 2-2-1 against the spread this season.

Notre Dame vs. Louisville: 2023 Stats Comparison

	Notre Dame	Louisville
Off. Points per Game (Rank)	36.5 (7)	37.0 (20)
Def. Points per Game (Rank)	13.0 (20)	17.2 (26)
Turnovers Allowed (Rank)	2 (3)	7 (66)
Turnovers Forced (Rank)	7 (55)	9 (24)

Notre Dame 2023 Key Players

Name	Position	Stats
Sam Hartman	QB	1,458 YDS (66.2%) / 14 TD / 0 INT 14 RUSH YDS / 2 RUSH TD / 2.3 RUSH YPG
Audric Estime	RB	672 YDS / 7 TD / 112.0 YPG / 7.1 YPC 9 REC / 80 REC YDS / 0 REC TD / 13.3 REC YPG
Chris Tyree	WR	11 REC / 269 YDS / 2 TD / 44.8 YPG
Holden Staes	TE	6 REC / 123 YDS / 4 TD / 20.5 YPG
Howard Cross III	DL	33 TKL / 1.0 TFL / 1.0 SACK
Xavier Watts	S	26 TKL / 0.0 TFL / 2 INT / 3 PD
Marist Liufau	LB	23 TKL / 1.0 TFL / 0.5 SACK
Jack Kiser	LB	26 TKL / 0.0 TFL / 1.0 SACK

Louisville 2023 Key Players

Name	Position	Stats
Jawhar Jordan	RB	510 YDS / 6 TD / 102.0 YPG / 7.7 YPC 7 REC / 159 REC YDS / 1 REC TD / 31.8 REC YPG
Jack Plummer	QB	1,406 YDS (65.2%) / 11 TD / 6 INT 79 RUSH YDS / 1 RUSH TD / 15.8 RUSH YPG
Jamari Thrash	WR	22 REC / 444 YDS / 5 TD / 88.8 YPG
Ahmari Huggins-Bruce	WR	13 REC / 191 YDS / 2 TD / 38.2 YPG
Ashton Gillotte	DL	13 TKL / 4.0 TFL / 4.0 SACK
TJ Quinn	LB	27 TKL / 0.0 TFL
Devin Neal	DB	16 TKL / 0.0 TFL / 1 INT / 1 PD
Jaylin Alderman	LB	18 TKL / 3.0 TFL / 1.0 SACK