Missouri State vs. New Mexico State Prediction, Odds, Picks - October 22, 2025

Updated Oct. 22, 2025 9:04 p.m. ET

Data Skrive

Oddsmakers project a close contest between CUSA foes when the Missouri State Bears (3-3) visit the New Mexico State Aggies (3-3) on Wednesday, October 22, 2025 at Aggie Memorial Stadium. New Mexico State is a 2.5-point underdogs. An over/under of 51.5 is set for the game.

Against the Middle Tennessee Blue Raiders in their most recent game, the Bears won 22-20. The Aggies lost against the Liberty Flames in their last game, 30-27.

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Missouri State vs. New Mexico State Game Information & Odds

When: Wednesday, October 22, 2025 at 9 p.m. ET
Location: Aggie Memorial Stadium in Las Cruces, New Mexico
TV: CBS Sports Network
Live Box Score on FOX Sports

Missouri State vs New Mexico State Betting Information updated as of October 22, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Missouri State	-2.5 (-116)	-143	+121	51.5	-109	-111

Missouri State vs. New Mexico State Prediction

Pick ATS: New Mexico State (+2.5)
Pick OU: Over (51.5)
Prediction: Missouri State 27, New Mexico State 25

Predictions are made by the Data Skrive betting model.

Learn more about the Missouri State Bears vs. the New Mexico State Aggies game on FOX Sports!

Missouri State vs. New Mexico State Betting Insights

Per the spread and over/under, the implied score for the game is Bears 27, Aggies 24.
The Bears have a 58.8% chance to claim victory in this contest based on the moneyline's implied probability. The Aggies hold a 45.2% implied probability.
Missouri State has compiled a 3-3-0 ATS record so far this year.
New Mexico State has compiled a 3-3-0 record against the spread this year.

Missouri State vs. New Mexico State: 2025 Stats Comparison

	Missouri State	New Mexico State
Off. Points per Game (Rank)	21.7 (124)	23 (117)
Def. Points per Game (Rank)	29.7 (78)	24 (43)
Turnovers Allowed (Rank)	8 (58)	9 (84)
Turnovers Forced (Rank)	8 (69)	12 (20)

Missouri State 2025 Key Players

Name	Position	Stats
Jacob Clark	QB	1,195 YDS (65.2%) / 8 TD / 6 INT 23 RUSH YDS / 2 RUSH TD / 4.6 RUSH YPG
Shomari Lawrence	RB	349 YDS / 2 TD / 58.2 YPG / 4.5 YPC 8 REC / 44 REC YDS / 0 REC TD / 11 REC YPG
Dash Luke	WR	24 REC / 335 YDS / 2 TD / 55.8 YPG
Ramone Green Jr.	RB	105 YDS / 0 TD / 17.5 YPG / 5 YPC 13 REC / 255 REC YDS / 1 REC TD / 42.5 REC YPG
Kanye Young	LB	23 TKL / 2 TFL / 1 SACK / 1 INT
Mitchell Toney	DL	15 TKL / 3 TFL / 2 SACK
Jalen Brooks	LB	18 TKL / 1 TFL
Jared Lloyd	LB	22 TKL / 2 TFL / 1 SACK

New Mexico State 2025 Key Players

Name	Position	Stats
Logan Fife	QB	1,512 YDS (56.5%) / 8 TD / 4 INT 18 RUSH YDS / 1 RUSH TD / 3 RUSH YPG
Donovan Faupel	WR	26 REC / 363 YDS / 2 TD / 60.5 YPG
Kadarius Calloway	RB	242 YDS / 3 TD / 40.3 YPG / 3.7 YPC 11 REC / 66 REC YDS / 0 REC TD / 11 REC YPG
PJ Johnson III	WR	14 REC / 215 YDS / 3 TD / 35.8 YPG
Ezra Christensen	DL	23 TKL / 5 TFL / 4 SACK
Jamall Thompson	DL	19 TKL / 3 TFL / 2 SACK / 1 INT
Naeten Mitchell	DB	29 TKL / 1 TFL / 1 INT / 1 PD
Tory Gethers	LB	24 TKL / 3 TFL / 2 SACK