Louisville vs. SMU Prediction, Odds, Picks - October 5, 2024

Updated Oct. 5, 2024 9:05 a.m. ET

Data Skrive

The No. 22 Louisville Cardinals (3-1) bring the No.25 scoring defense in college football into a matchup with the SMU Mustangs (4-1), who have the No. 13 scoring offense, on Saturday, October 5, 2024. The Cardinals are 6.5-point favorites. The contest's point total is set at 55.5.

The Cardinals lost against the Notre Dame Fighting Irish in their most recent game, 31-24. The Mustangs' last contest was against the Florida State Seminoles, and they won by a score of 42-16.

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Louisville vs. SMU Game Information & Odds

When: Saturday, October 5, 2024 at 12:00 p.m. ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ESPN
Live Box Score on FOX Sports

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Louisville vs SMU Betting Information updated as of October 5, 2024, 8:46 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-6.5 (-116)	-249	+201	55.5	-110	-110

Louisville vs. SMU Prediction

Pick ATS: SMU (+6.5)
Pick OU: Over (55.5)
Prediction: Louisville 32, SMU 28

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the SMU Mustangs game on FOX Sports!

Louisville vs. SMU Betting Insights

Based on the spread and over/under, the implied score for the tilt is Cardinals 31, Mustangs 24.
The Cardinals have a 71.3% chance to claim victory in this meeting based on the moneyline's implied probability. The Mustangs have a 33.2% implied probability.
Louisville has a record of 2-1-0 against the spread this season.
SMU has covered twice in four chances against the spread this season.

Louisville vs. SMU: 2024 Stats Comparison

	Louisville	SMU
Off. Points per Game (Rank)	41.5 (34)	42.2 (8)
Def. Points per Game (Rank)	16 (17)	21.4 (64)
Turnovers Allowed (Rank)	3 (15)	7 (81)
Turnovers Forced (Rank)	6 (62)	14 (1)

Louisville 2024 Key Players

Name	Position	Stats
Tyler Shough	QB	1,114 YDS (65%) / 11 TD / 1 INT 51 RUSH YDS / 0 RUSH TD / 12.8 RUSH YPG
Ja'Corey Brooks	WR	22 REC / 368 YDS / 4 TD / 92 YPG
Isaac Brown	RB	245 YDS / 1 TD / 61.3 YPG / 8.4 YPC 8 REC / 47 REC YDS / 1 REC TD / 11.8 REC YPG
Keyjuan Brown	RB	149 YDS / 2 TD / 37.3 YPG / 6.2 YPC 5 REC / 53 REC YDS / 0 REC TD / 13.3 REC YPG
Tramel Logan	DL	4 TKL / 2 TFL / 3 SACK
Jared Dawson	DL	9 TKL / 3 TFL / 2 SACK
Tamarion McDonald	DB	6 TKL / 3 TFL / 2 SACK
Stanquan Clark	LB	13 TKL / 1 TFL

SMU 2024 Key Players

Name	Position	Stats
Brashard Smith	RB	506 YDS / 7 TD / 101.2 YPG / 7.3 YPC 11 REC / 121 REC YDS / 1 REC TD / 24.2 REC YPG
Kevin Jennings	QB	733 YDS (63.4%) / 6 TD / 1 INT 149 RUSH YDS / 1 RUSH TD / 29.8 RUSH YPG
RJ Maryland	TE	16 REC / 221 YDS / 3 TD / 44.2 YPG
Jordan Hudson	WR	8 REC / 112 YDS / 3 TD / 22.4 YPG
Kobe Wilson	LB	31 TKL / 1 TFL / 2 INT / 2 PD
Ahmad Walker	LB	27 TKL / 2 TFL / 1 INT / 1 PD
Ahmaad Moses	DB	21 TKL / 1 TFL / 3 INT / 3 PD
Isaiah Nwokobia	DB	29 TKL / 1 TFL / 0.5 SACK