Louisville vs. Duke Prediction, Odds, Picks - October 28

Updated Oct. 28, 2023 3:06 p.m. ET

FOX Sports

The No. 18 Louisville Cardinals (6-1) and the 15th-ranked run defense will host the No. 20 Duke Blue Devils (5-2) and the 19th-ranked run offense on Saturday, October 28, 2023. The Blue Devils are 6.5-point underdogs. The contest has a point total set at 45.

The Cardinals lost against the Pittsburgh Panthers in their most recent game, 38-21. The Blue Devils' most recent game was against the Florida State Seminoles, and they lost by a score of 38-20.

Louisville vs. Duke Game Information & Odds

When: Saturday, October 28, 2023 at 3:30 PM ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ESPN
Live boxscore on FOX Sports

Louisville vs Duke Betting Information updated as of October 28, 2023, 2:46 PM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-6.5 (-110)	-239	+193	45	-161	-164

Louisville vs. Duke Prediction

Pick ATS: Duke (+6.5)
Pick OU: Over (45)
Prediction: Duke 27, Louisville 22

Learn more about the Louisville Cardinals vs. the Duke Blue Devils game on FOX Sports!

Louisville vs. Duke Betting Insights

Per the spread and over/under, the implied score for the tilt is Cardinals 26, Blue Devils 19.
The Cardinals have a 70.5% chance to claim victory in this meeting based on the moneyline's implied probability. The Blue Devils have a 34.1% implied probability.
Louisville has put together a 3-3-1 ATS record so far this year.
Duke has won four games against the spread this year, failing to cover twice.

Louisville vs. Duke: 2023 Stats Comparison

	Louisville	Duke
Off. Points per Game (Rank)	34.1 (36)	29.6 (71)
Def. Points per Game (Rank)	20.6 (35)	13.9 (5)
Turnovers Allowed (Rank)	11 (80)	7 (25)
Turnovers Forced (Rank)	14 (13)	10 (62)

Louisville 2023 Key Players

Name	Position	Stats
Jawhar Jordan	RB	661 YDS / 8 TD / 94.4 YPG / 7.4 YPC 10 REC / 174 REC YDS / 1 REC TD / 24.9 REC YPG
Jack Plummer	QB	1,901 YDS (63.5%) / 13 TD / 8 INT 34 RUSH YDS / 1 RUSH TD / 4.9 RUSH YPG
Jamari Thrash	WR	39 REC / 639 YDS / 6 TD / 91.3 YPG
Isaac Guerendo	RB	207 YDS / 3 TD / 29.6 YPG / 4.0 YPC 12 REC / 133 REC YDS / 0 REC TD / 19.0 REC YPG
Devin Neal	DB	28 TKL / 0.0 TFL / 3 INT / 3 PD
Ashton Gillotte	DL	16 TKL / 5.0 TFL / 5.5 SACK
TJ Quinn	LB	44 TKL / 0.0 TFL
Ramon Puryear	DL	12 TKL / 3.0 TFL / 2.0 SACK / 1 INT

Duke 2023 Key Players

Name	Position	Stats
Jordan Waters	RB	465 YDS / 9 TD / 66.4 YPG / 6.0 YPC 6 REC / 84 REC YDS / 0 REC TD / 12.0 REC YPG
Riley Leonard	QB	981 YDS (60.6%) / 3 TD / 2 INT 339 RUSH YDS / 4 RUSH TD / 48.4 RUSH YPG
Jaquez Moore	RB	390 YDS / 3 TD / 55.7 YPG / 5.7 YPC
Jordan Moore	WR	27 REC / 348 YDS / 3 TD / 49.7 YPG
Tre Freeman	LB	51 TKL / 1.0 TFL / 0.5 SACK / 1 INT
Dorian Mausi	LB	43 TKL / 2.0 TFL / 0.5 SACK / 1 INT
Brandon Johnson	DB	29 TKL / 6.0 TFL / 2.0 SACK
Chandler Rivers	CB	33 TKL / 1.0 TFL / 1 INT / 1 PD