James Madison vs. Old Dominion Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

FOX Sports

The James Madison Dukes (5-1) take college football's third-ranked rushing defense into a matchup with the Old Dominion Monarchs (4-2), who have the No. 10 rushing attack, on Saturday, October 18, 2025. The Dukes are only 2.5-point favorites. This matchup has an over/under of 47.5 points.

The Dukes' last game was versus the Louisiana Ragin' Cajuns, and they won by a score of 24-14. The Monarchs lost to the Marshall Thundering Herd, 48-24, in their last game.

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James Madison vs. Old Dominion Game Information & Odds

When: Saturday, October 18, 2025 at 3:30 p.m. ET
Location: Bridgeforth Stadium/Zane Showker Field in Harrisonburg, Virginia
TV: ESPNU
Live Box Score on FOX Sports

James Madison vs Old Dominion Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
James Madison	-2.5 (-122)	-149	+125	47.5	-111	-109

James Madison vs. Old Dominion Prediction

Pick ATS: Old Dominion (+2.5)
Pick OU: Under (47.5)
Prediction: Old Dominion 24, James Madison 22

Predictions are made by the Data Skrive betting model.

Learn more about the James Madison Dukes vs. the Old Dominion Monarchs game on FOX Sports!

James Madison vs. Old Dominion Betting Insights

Per the spread and over/under, the implied score for the matchup is Dukes 25, Monarchs 22.
The Dukes have a 59.8% chance to collect the win in this meeting per the moneyline's implied probability. The Monarchs have a 44.4% implied probability.
James Madison has won four games against the spread this season, while failing to cover twice.
Old Dominion has covered four times in six games with a spread this year.

James Madison vs. Old Dominion: Head-to-Head

In their last three head-to-head contests, James Madison has defeated Old Dominion three times.
The Dukes carry a 2-1 record ATS in those games, while the two teams have gone over the total on two occasions.
Over their last three head-to-head contests, James Madison has put up 102 points, while Old Dominion has accumulated 62.

James Madison vs. Old Dominion: 2025 Stats Comparison

	James Madison	Old Dominion
Off. Points per Game (Rank)	27.2 (83)	34.2 (46)
Def. Points per Game (Rank)	13.7 (9)	20.2 (38)
Turnovers Allowed (Rank)	8 (76)	15 (134)
Turnovers Forced (Rank)	5 (104)	12 (12)

James Madison 2025 Key Players

Name	Position	Stats
Alonza Barnett III	QB	957 YDS (60.3%) / 7 TD / 2 INT 113 RUSH YDS / 5 RUSH TD / 18.8 RUSH YPG
Wayne Knight	RB	537 YDS / 4 TD / 89.5 YPG / 6.6 YPC 21 REC / 138 REC YDS / 0 REC TD / 23 REC YPG
Landon Ellis	WR	19 REC / 303 YDS / 5 TD / 50.5 YPG
Jordan Fuller	RB	312 YDS / 1 TD / 78 YPG / 5.9 YPC
Trent Hendrick	LB	25 TKL / 4 TFL / 3 SACK
Jacob Thomas	DB	19 TKL / 0 TFL / 1 SACK / 2 INT
Sahir West	DL	14 TKL / 4 TFL / 2.5 SACK
Aiden Gobaira	DL	7 TKL / 5 TFL / 3 SACK

Old Dominion 2025 Key Players

Name	Position	Stats
Colton Joseph	QB	1,481 YDS (63.2%) / 13 TD / 6 INT 486 RUSH YDS / 6 RUSH TD / 81 RUSH YPG
Trequan Jones	RB	477 YDS / 4 TD / 95.4 YPG / 8.8 YPC
Na'eem Abdul-Rahim Gladding	WR	25 REC / 366 YDS / 5 TD / 61 YPG
Ja'Cory Thomas	WR	22 REC / 397 YDS / 3 TD / 66.2 YPG
Jerome Carter	DB	24 TKL / 1 TFL / 2 INT / 2 PD
Jeremy Mack Jr.	LB	13 TKL / 2 TFL / 2 SACK / 1 INT
Keshawn Thomas	LB	15 TKL / 3 TFL / 2.5 SACK
Jackson Forrest	LB	11 TKL / 0 TFL / 1.5 SACK