Iowa State vs. Arkansas State Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

Data Skrive

The No. 14 Iowa State Cyclones (3-0) are heavy 21.5-point favorites on Saturday, September 13, 2025 against the Arkansas State Red Wolves (1-1). An over/under of 55.5 is set for the game.

The Cyclones won against the Iowa Hawkeyes in their most recent game, 16-13. In their most recent game, the Red Wolves lost versus the Arkansas Razorbacks, 56-14.

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Iowa State vs. Arkansas State Game Information & Odds

When: Saturday, September 13, 2025 at 4 p.m. ET
Location: Centennial Bank Stadium in Jonesboro, Arkansas
TV: ESPN2
Live Box Score on FOX Sports

Iowa State vs Arkansas State Betting Information updated as of September 13, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa State	-21.5 (-109)	-1724	+942	55.5	-112	-108

Iowa State vs. Arkansas State Prediction

Pick ATS: Arkansas State (+21.5)
Pick OU: Under (55.5)
Prediction: Iowa State 33, Arkansas State 20

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Arkansas State Red Wolves game on FOX Sports!

Iowa State vs. Arkansas State Betting Insights

Per the spread and over/under, the implied score for the tilt is Cyclones 38, Red Wolves 17.
The Cyclones have a 94.5% chance to collect the win in this game based on the moneyline's implied probability. The Red Wolves hold a 9.6% implied probability.
Iowa State has a record of 2-0-1 against the spread this season.
Arkansas State has a record of 1-1-0 against the spread this season.

Iowa State vs. Arkansas State: 2025 Stats Comparison

	Iowa State	Arkansas State
Off. Points per Game (Rank)	31.7 (23)	28 (75)
Def. Points per Game (Rank)	13.7 (66)	40 (124)
Turnovers Allowed (Rank)	3 (83)	3 (83)
Turnovers Forced (Rank)	5 (7)	3 (37)

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	595 YDS (68%) / 6 TD / 0 INT 44 RUSH YDS / 1 RUSH TD / 14.7 RUSH YPG
Benjamin Brahmer	TE	13 REC / 106 YDS / 3 TD / 35.3 YPG
Brett Eskildsen	WR	7 REC / 162 YDS / 1 TD / 54 YPG
Gabe Burkle	TE	10 REC / 149 YDS / 1 TD / 49.7 YPG
Marcus Neal	DB	21 TKL / 3 TFL / 1 SACK
Jamison Patton	DB	18 TKL / 0 TFL / 1 INT / 1 PD
Tamatoa McDonough	DL	8 TKL / 2 TFL / 2 SACK
Kooper Ebel	LB	12 TKL / 1 TFL / 1 SACK

Arkansas State 2025 Key Players

Name	Position	Stats
Jaylen Raynor	QB	470 YDS (72.3%) / 4 TD / 2 INT 55 RUSH YDS / 0 RUSH TD / 27.5 RUSH YPG
Chauncy Cobb	WR	9 REC / 135 YDS / 0 TD / 67.5 YPG
Ja'Quez Cross	RB	36 YDS / 1 TD / 36 YPG / 4.5 YPC 5 REC / 33 REC YDS / 1 REC TD / 33 REC YPG
Kenyon Clay	RB	69 YDS / 1 TD / 34.5 YPG / 2.6 YPC 5 REC / 22 REC YDS / 0 REC TD / 11 REC YPG
Terry Kirksey Jr.	LB	12 TKL / 0 TFL / 1 INT / 1 PD
Nigel Nelson	LB	16 TKL / 0 TFL
AG McGhee	DB	11 TKL / 1 TFL
Cody Sigler	DL	5 TKL / 1 TFL / 1.5 SACK