Indiana vs. Purdue Prediction, Odds, Picks - November 28, 2025

Updated Nov. 28, 2025 3:05 p.m. ET

FOX Sports

Oddsmakers massively favor the No. 2 Indiana Hoosiers (11-0) when they visit the Purdue Boilermakers (2-9) on Friday, November 28, 2025 in a matchup between Big Ten rivals at Ross-Ade Stadium. Indiana is favored by 28.5 points. The game has an over/under of 53.5 points.

The Hoosiers won against the Wisconsin Badgers in their last game, 31-7. The Boilermakers' most recent game was against the Washington Huskies, and they lost by a score of 49-13.

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Indiana vs. Purdue Game Information & Odds

When: Friday, November 28, 2025 at 7:30 p.m. ET
Location: Ross-Ade Stadium in West Lafayette, Indiana
TV: NBC
Live Box Score on FOX Sports

Indiana vs Purdue Betting Information updated as of November 28, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-28.5 (-109)	-6250	+1850	53.5	-109	-111

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Indiana vs. Purdue Prediction

Pick ATS: Indiana (-28.5)
Pick OU: Under (53.5)
Prediction: Indiana 42, Purdue 9

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Purdue Boilermakers game on FOX Sports!

Indiana vs. Purdue Betting Insights

Per the spread and over/under, the implied score for the matchup is Hoosiers 41, Boilermakers 12.
The Hoosiers have a 98.4% chance to claim victory in this meeting per the moneyline's implied probability. The Boilermakers have a 5.1% implied probability.
Indiana has compiled a 6-5-0 ATS record so far this year.
Purdue has covered five times in 11 matchups with a spread this year.

Indiana vs. Purdue: Head-to-Head

In their past four head-to-head matchups, Purdue has beaten Indiana three times.
In their past four meetings, each team has covered two times with those games outpacing the point total on three occasions.
Over their last four head-to-head contests, Indiana has put up 120 points, while Purdue has compiled 109.

Indiana vs. Purdue: 2025 Stats Comparison

	Indiana	Purdue
Off. Points per Game (Rank)	43.3 (2)	20.2 (119)
Def. Points per Game (Rank)	11.6 (2)	29.6 (102)
Turnovers Allowed (Rank)	7 (4)	19 (118)
Turnovers Forced (Rank)	22 (8)	9 (116)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	2,641 YDS (73%) / 30 TD / 5 INT 216 RUSH YDS / 5 RUSH TD / 19.6 RUSH YPG
Omar Cooper Jr.	WR	56 REC / 764 YDS / 10 TD / 69.5 YPG
Elijah Sarratt	WR	44 REC / 585 YDS / 10 TD / 65 YPG
Roman Hemby	RB	714 YDS / 5 TD / 64.9 YPG / 4.7 YPC 13 REC / 153 REC YDS / 0 REC TD / 15.3 REC YPG
Rolijah Hardy	LB	56 TKL / 9 TFL / 7 SACK
Isaiah Jones	LB	46 TKL / 9 TFL / 5 SACK / 1 INT
Aiden Fisher	LB	50 TKL / 5 TFL / 2.5 SACK / 2 INT
Louis Moore	DB	54 TKL / 2 TFL / 4 INT / 4 PD

Purdue 2025 Key Players

Name	Position	Stats
Ryan Browne	QB	1,915 YDS (59.8%) / 9 TD / 9 INT 203 RUSH YDS / 4 RUSH TD / 18.5 RUSH YPG
Devin Mockobee	RB	521 YDS / 4 TD / 65.1 YPG / 4.2 YPC 18 REC / 215 REC YDS / 1 REC TD / 26.9 REC YPG
Nitro Tuggle	WR	29 REC / 425 YDS / 4 TD / 38.6 YPG
Malachi Singleton	QB	439 YDS (59.4%) / 5 TD / 2 INT 204 RUSH YDS / 1 RUSH TD / 20.4 RUSH YPG
Mani Powell	LB	82 TKL / 7 TFL / 5 SACK
CJ Nunnally	DL	38 TKL / 8 TFL / 5 SACK / 1 INT
Tahj Ra-El	DB	74 TKL / 1 TFL
Charles Correa	LB	65 TKL / 3 TFL / 2 SACK