Indiana vs. Maryland Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

FOX Sports

A pair of the nation's best defenses square off when the No. 2 Indiana Hoosiers (8-0) take college football's third-ranked scoring defense into a matchup with the Maryland Terrapins (4-3), who have the No. 18 scoring defense, on Saturday, November 1, 2025. The Hoosiers are heavy, 21-point favorites. The game has an over/under of 50.5.

In their most recent action, the Hoosiers won against the UCLA Bruins, 56-6. Last time out, the Terrapins fell to the UCLA Bruins, with 20-17 being the final score.

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Indiana vs. Maryland Game Information & Odds

When: Saturday, November 1, 2025 at 3:30 p.m. ET
Location: SECU Stadium in College Park, Maryland
TV: CBS
Live Box Score on FOX Sports

Indiana vs Maryland Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-21 (-110)	-1961	+1018	50.5	-110	-110

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Indiana vs. Maryland Prediction

Pick ATS: Indiana (-21)
Pick OU: Under (50.5)
Prediction: Indiana 36, Maryland 12

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Maryland Terrapins game on FOX Sports!

Indiana vs. Maryland Betting Insights

Based on the spread and over/under, the implied score for the game is Hoosiers 36, Terrapins 15.
The Hoosiers have a 95.1% chance to collect the win in this game per the moneyline's implied probability. The Terrapins hold an 8.9% implied probability.
Indiana has covered five times in eight matchups with a spread this season.
Maryland has put together a 5-2-0 record against the spread this year.

Indiana vs. Maryland: Head-to-Head

Over their last four meetings, Maryland has three wins against Indiana.
In those contests versus Maryland, the Hoosiers have covered three times while eclipsing the point total each time.
Indiana has been outscored by 21 points in its last four tilts against Maryland.

Indiana vs. Maryland: 2025 Stats Comparison

	Indiana	Maryland
Off. Points per Game (Rank)	45.4 (3)	28.3 (88)
Def. Points per Game (Rank)	10.9 (3)	17.3 (13)
Turnovers Allowed (Rank)	5 (9)	5 (9)
Turnovers Forced (Rank)	13 (28)	16 (7)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	1,923 YDS (72.9%) / 24 TD / 3 INT 196 RUSH YDS / 3 RUSH TD / 24.5 RUSH YPG
Elijah Sarratt	WR	44 REC / 585 YDS / 10 TD / 73.1 YPG
Omar Cooper Jr.	WR	40 REC / 607 YDS / 7 TD / 75.9 YPG
Roman Hemby	RB	513 YDS / 4 TD / 64.1 YPG / 4.8 YPC 10 REC / 131 REC YDS / 0 REC TD / 18.7 REC YPG
Isaiah Jones	LB	39 TKL / 9 TFL / 5 SACK / 1 INT
Louis Moore	DB	48 TKL / 2 TFL / 3 INT / 3 PD
Rolijah Hardy	LB	37 TKL / 7 TFL / 5 SACK
Aiden Fisher	LB	41 TKL / 5 TFL / 2.5 SACK / 1 INT

Maryland 2025 Key Players

Name	Position	Stats
Malik Washington	QB	1,716 YDS (59.7%) / 11 TD / 3 INT 112 RUSH YDS / 3 RUSH TD / 16 RUSH YPG
Shaleak Knotts	WR	26 REC / 421 YDS / 5 TD / 60.1 YPG
DeJuan Williams	RB	292 YDS / 2 TD / 41.7 YPG / 3.5 YPC 20 REC / 194 REC YDS / 0 REC TD / 27.7 REC YPG
Octavian Smith Jr.	WR	27 REC / 378 YDS / 0 TD / 54 YPG
Daniel Wingate	LB	63 TKL / 3 TFL / 1.5 SACK / 1 INT
Sidney Stewart	DL	19 TKL / 5 TFL / 5.5 SACK
Jalen Huskey	DB	33 TKL / 1 TFL / 3 INT / 3 PD
Zahir Mathis	DL	23 TKL / 5 TFL / 4.5 SACK