Clemson vs. Syracuse Prediction, Odds, Picks - September 20, 2025

The Clemson Tigers (1-2) host the Syracuse Orange (2-1) on Saturday, September 20, 2025 in a matchup between ACC rivals at Memorial Stadium (Clemson, SC). Syracuse is a 17-point underdog. The game's point total is 54.5.

In their last action, the Tigers lost against the Georgia Tech Yellow Jackets, 24-21. In their most recent contest, the Orange won versus the Colgate Raiders, 66-24.

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Clemson vs. Syracuse Game Information & Odds

• When: Saturday, September 20, 2025 at 12 p.m. ET
• Location: Memorial Stadium (Clemson, SC) in Clemson, South Carolina
• TV: ESPN
• Live Box Score on FOX Sports

Clemson vs. Syracuse Prediction

• Pick ATS: Syracuse (+17)
  
• Pick OU: Under (54.5)
  
• Prediction: Clemson 30, Syracuse 18

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the Syracuse Orange game on FOX Sports!

Clemson vs. Syracuse Betting Insights

• Based on the spread and over/under, the implied score for the game is Tigers 36, Orange 19.
• The Tigers have an 89.4% chance to win this contest based on the moneyline's implied probability. The Orange hold a 14.8% implied probability.
• Clemson is winless against the spread this season (0-3-0).
• Syracuse has won one game against the spread this season.

Clemson vs. Syracuse: Head-to-Head

• In their last three head-to-head bouts, Clemson has beaten Syracuse three times.
• In those contests against Clemson, the Orange have covered two times while never hitting the over on the point total.
• Over their last three head-to-head matchups, Clemson has put up 75 points, while Syracuse has accumulated 49.

Clemson vs. Syracuse: 2025 Stats Comparison

Clemson 2025 Key Players

Syracuse 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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