Clemson vs. Syracuse Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 a.m. ET

FOX Sports

The Clemson Tigers (1-2) host the Syracuse Orange (2-1) on Saturday, September 20, 2025 in a matchup between ACC rivals at Memorial Stadium (Clemson, SC). Syracuse is a 17-point underdog. The game's point total is 54.5.

In their last action, the Tigers lost against the Georgia Tech Yellow Jackets, 24-21. In their most recent contest, the Orange won versus the Colgate Raiders, 66-24.

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Clemson vs. Syracuse Game Information & Odds

When: Saturday, September 20, 2025 at 12 p.m. ET
Location: Memorial Stadium (Clemson, SC) in Clemson, South Carolina
TV: ESPN
Live Box Score on FOX Sports

Clemson vs Syracuse Betting Information updated as of September 20, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Clemson	-17 (-110)	-847	+574	54.5	-109	-111

Clemson vs. Syracuse Prediction

Pick ATS: Syracuse (+17)
Pick OU: Under (54.5)
Prediction: Clemson 30, Syracuse 18

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the Syracuse Orange game on FOX Sports!

Clemson vs. Syracuse Betting Insights

Based on the spread and over/under, the implied score for the game is Tigers 36, Orange 19.
The Tigers have an 89.4% chance to win this contest based on the moneyline's implied probability. The Orange hold a 14.8% implied probability.
Clemson is winless against the spread this season (0-3-0).
Syracuse has won one game against the spread this season.

Clemson vs. Syracuse: Head-to-Head

In their last three head-to-head bouts, Clemson has beaten Syracuse three times.
In those contests against Clemson, the Orange have covered two times while never hitting the over on the point total.
Over their last three head-to-head matchups, Clemson has put up 75 points, while Syracuse has accumulated 49.

Clemson vs. Syracuse: 2025 Stats Comparison

	Clemson	Syracuse
Off. Points per Game (Rank)	19.3 (109)	39.7 (30)
Def. Points per Game (Rank)	19 (56)	29.7 (108)
Turnovers Allowed (Rank)	5 (104)	6 (117)
Turnovers Forced (Rank)	5 (26)	4 (47)

Clemson 2025 Key Players

Name	Position	Stats
Bryant Wesco Jr.	WR	18 REC / 310 YDS / 3 TD / 103.3 YPG
Cade Klubnik	QB	633 YDS (59.1%) / 3 TD / 3 INT 59 RUSH YDS / 1 RUSH TD / 19.7 RUSH YPG
Adam Randall	RB	208 YDS / 3 TD / 69.3 YPG / 5.1 YPC 6 REC / 37 REC YDS / 0 REC TD / 18.5 REC YPG
Tyler Brown	WR	10 REC / 95 YDS / 0 TD / 31.7 YPG
Ronan Hanafin	DB	28 TKL / 0 TFL / 1 INT / 1 PD
Avieon Terrell	DB	16 TKL / 1 TFL / 1 SACK
Wade Woodaz	LB	25 TKL / 2 TFL
Will Heldt	DL	12 TKL / 5 TFL / 2 SACK

Syracuse 2025 Key Players

Name	Position	Stats
Steve Angeli	QB	1,108 YDS (64%) / 8 TD / 2 INT -38 RUSH YDS / 1 RUSH TD / -12.7 RUSH YPG
Darrell Gill Jr.	WR	12 REC / 269 YDS / 2 TD / 89.7 YPG
Yasin Willis	RB	139 YDS / 4 TD / 69.5 YPG / 4.1 YPC
Justus Ross-Simmons	WR	9 REC / 159 YDS / 3 TD / 53 YPG
Darian Chestnut	DB	21 TKL / 0 TFL
Braheem Long Jr.	DB	8 TKL / 1 TFL / 1 SACK / 1 INT
Demetres Samuel Jr.	DB	13 TKL / 0 TFL / 1 INT / 1 PD
Gary Bryant III	LB	16 TKL / 0 TFL