Clemson vs. Florida State Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

Data Skrive

The Clemson Tigers (3-5) will put their 20th-ranked run defense to the test against the Florida State Seminoles (4-4) and the No. 8 rushing offense in the country, on Saturday, November 8, 2025. The Tigers are favored by just 1.5 points in the outing. The point total is set at 56.5 for the outing.

In their last action, the Tigers lost against the Duke Blue Devils, 46-45. Facing the Wake Forest Demon Deacons in their most recent contest, the Seminoles won 42-7.

Keep up with college football all season on FOX Sports.

Clemson vs. Florida State Game Information & Odds

When: Saturday, November 8, 2025 at 7 p.m. ET
Location: Memorial Stadium (Clemson, SC) in Clemson, South Carolina
TV: ACC Network
Live Box Score on FOX Sports

Clemson vs Florida State Betting Information updated as of November 8, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Clemson	-1.5 (-110)	-123	+103	56.5	-109	-111

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Clemson vs. Florida State Prediction

Pick ATS: Florida State (+1.5)
Pick OU: Under (56.5)
Prediction: Florida State 34, Clemson 21

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the Florida State Seminoles game on FOX Sports!

Clemson vs. Florida State Betting Insights

Based on the spread and over/under, the implied score for the game is Tigers 29, Seminoles 28.
The Tigers have a 55.2% chance to win this meeting per the moneyline's implied probability. The Seminoles have a 49.3% implied probability.
Clemson has a record of just 2-6-0 against the spread this season.
Florida State has compiled a 3-4-0 ATS record so far this year.

Clemson vs. Florida State: Head-to-Head

Over their last four meetings, Clemson has put up three wins versus Florida State.
In their most recent four head-to-head meetings, each team has covered two times with those games hitting the over on the total on two occasions.
Florida State has been outpaced by 25 points in its last four tilts against Clemson.

Clemson vs. Florida State: 2025 Stats Comparison

	Clemson	Florida State
Off. Points per Game (Rank)	28.4 (79)	40 (16)
Def. Points per Game (Rank)	24 (45)	20.6 (25)
Turnovers Allowed (Rank)	13 (99)	11 (70)
Turnovers Forced (Rank)	8 (98)	11 (56)

Clemson 2025 Key Players

Name	Position	Stats
Cade Klubnik	QB	1,915 YDS (67.2%) / 13 TD / 5 INT 116 RUSH YDS / 2 RUSH TD / 16.6 RUSH YPG
Adam Randall	RB	522 YDS / 6 TD / 65.3 YPG / 5.2 YPC 25 REC / 192 REC YDS / 3 REC TD / 27.4 REC YPG
Bryant Wesco Jr.	WR	31 REC / 537 YDS / 6 TD / 76.7 YPG
T.J. Moore	WR	28 REC / 499 YDS / 4 TD / 62.4 YPG
Sammy Brown	LB	52 TKL / 4 TFL / 2 SACK
Ronan Hanafin	DB	42 TKL / 0 TFL / 1 INT / 1 PD
Wade Woodaz	LB	46 TKL / 2 TFL / 0.5 SACK
Avieon Terrell	DB	33 TKL / 1 TFL / 1 SACK

Florida State 2025 Key Players

Name	Position	Stats
Thomas Castellanos	QB	1,878 YDS (61.5%) / 10 TD / 5 INT 328 RUSH YDS / 6 RUSH TD / 41 RUSH YPG
Gavin Sawchuk	RB	432 YDS / 8 TD / 54 YPG / 4.6 YPC 9 REC / 102 REC YDS / 1 REC TD / 14.6 REC YPG
Micahi Danzy	WR	21 REC / 503 YDS / 2 TD / 62.9 YPG
Duce Robinson	WR	34 REC / 689 YDS / 4 TD / 86.1 YPG
Earl Little II	DB	52 TKL / 1 TFL / 4 INT / 5 PD
Ja'Bril Rawls	DB	37 TKL / 2 TFL / 1 INT / 1 PD
Elijah Herring	LB	28 TKL / 2 TFL / 1 SACK / 1 INT
Ashlynd Barker	DB	28 TKL / 2 TFL / 2.5 SACK