Louisville vs. Creighton Prediction, Odds, Picks - NCAA Tournament First Round

Updated Mar. 20, 2025 10:27 a.m. ET

Data Skrive

The No. 8 seed Louisville Cardinals (27-7) will aim to defeat the No. 9 seed Creighton Bluejays (24-10) in the opening round of the NCAA Tournament on Thursday at Rupp Arena. This matchup tips off at 12:15 p.m. ET.

The Cardinals, who are favored by 2.5 points, are set to face the Bluejays. The game's point total is set at 145.5.

Continue reading to get everything you need to know before betting on the Louisville-Creighton contest.

Louisville vs. Creighton Game Information & Odds

When: Thursday, March 20, 2025 at 12:15 p.m. ET
Where: Rupp Arena in Lexington, Kentucky
How to watch on TV: CBS
Live boxscore on FOX Sports

Cardinals vs Bluejays Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cardinals	-2.5	-115	-105	145.5	-112	-108	-155	+130

Louisville vs. Creighton Prediction

Pick ATS: Louisville (-2.5)
Pick OU: Over (145.5)
Prediction: Louisville 75, Creighton 71

Learn more about the Louisville Cardinals vs. the Creighton Bluejays game on FOX Sports!

Louisville vs. Creighton Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Cardinals 74, Bluejays 72.
The Cardinals have a 60.8% chance to collect the win in this meeting per the moneyline's implied probability.
The Bluejays sit with a 43.5% implied probability to win.

Key Spread Facts

Louisville is 20-13-0 ATS this season.
Creighton has covered 21 times in 34 chances against the spread this year.
Louisville has an ATS record of 13-10 when playing as at least 2.5-point favorites this season.
When playing as at least 2.5-point underdogs this season, Creighton has an ATS record of 7-1.

Key Total Facts

A total of 20 times so far this season, the Cardinals and their opponent have combined to score more than 145.5 points.
There have been 17 Bluejays games this season with more than 145.5 points scored.
The Cardinals and Bluejays combine to average 153.8 points per contest, which is 8.3 more than the total for this game.

Key Moneyline Facts

Louisville has been favored on the moneyline 25 times this season. They've finished 21-4 in those games.
Creighton has been underdogs in 10 games this season and won four (40%) of those contests.
Louisville has gone 20-2 when playing as a moneyline favorite with odds of -155 or shorter (winning 90.9%).
Creighton has a record of 3-5 when it is set as the underdog by +130 or more by bookmakers this season.

Louisville vs. Creighton: 2024-25 Stats Comparison

	Louisville	Creighton
Points Scored Per Game (Rank)	78.6 (68)	75.2 (137)
Points Allowed (Rank)	68.9 (83)	69.5 (97)
Rebounds (Rank)	9.7 (112)	7.5 (290)
3pt Made (Rank)	9.4 (45)	9.4 (45)
Assists (Rank)	14 (143)	17.1 (14)
Turnovers (Rank)	11 (162)	11.5 (219)

Louisville 2024-25 Key Players

Cardinals Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Terrence Edwards	34	16.6	4.1	2.6	0.7	0.2	1.9
Chucky Hepburn	33	16.2	3.5	5.8	2.5	0.1	1.8
Reyne Smith	30	13.4	2.8	0.8	0.7	0.1	3.5
J'Vonne Hadley	34	12.1	7.3	1.9	0.7	0.2	0.9
Kasean Pryor	7	12	6.1	2.1	1.6	1.1	0.7

Creighton 2024-25 Key Players

Bluejays Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Ryan Kalkbrenner	33	19.4	8.8	1.5	0.6	2.7	0.6
Steven Ashworth	33	16.3	4.1	6.8	0.7	0.1	3.1
Pop Isaacs	8	16.3	4.8	3.9	0.5	0.1	2.9
Jamiya Neal	34	11.5	6.1	4.4	0.9	0.6	1.3
Jackson McAndrew	34	7.6	4.5	0.4	0.4	0.1	1.8