Houston vs. Duke Prediction, Odds, Picks - NCAA Tournament Sweet 16

Updated Mar. 29, 2024 8:27 p.m. ET

Data Skrive

A Sweet 16 battle will feature the No. 1 seed Houston Cougars (32-4) and the No. 4 seed Duke Blue Devils (26-8) playing on Friday at American Airlines Center. The NCAA Tournament contest begins at 9:39 PM ET.

The Cougars are a 4.5-point favorite against the Blue Devils when the Cougars and the Blue Devils meet. The game's over/under is set at 133.5.

Continue scrolling to get all you need to know ahead of betting on the Houston-Duke contest.

Houston vs. Duke Game Information & Odds

When: Friday, March 29, 2024 at 9:39 PM ET
Where: American Airlines Center in Dallas, Texas
How to Watch on TV: CBS
Live boxscore on FOX Sports

Cougars vs Blue Devils Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cougars	-4.5	-105	-115	133.5	-110	-110	-218	+180

Houston vs. Duke Prediction

Pick ATS: Duke (+4.5)
Pick OU: Over (133.5)
Prediction: Houston 71, Duke 68

Learn more about the Houston Cougars vs. the Duke Blue Devils game on FOX Sports!

Houston vs. Duke Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Cougars 69, Blue Devils 64.
The Cougars have a 68.6% chance to win this game based on the moneyline's implied probability.
The Blue Devils have a 35.7% implied probability to come out on top.

Key Spread Facts

Houston has compiled an 18-16-1 ATS record so far this year.
Duke has won 19 games against the spread this season, while failing to cover or pushing 13 times.
Houston has an ATS record of 16-13-1 when playing as at least 4.5-point favorites this season.
Duke has not covered the spread when an underdog by 4.5 points or more this year (in one opportunity).

Key Total Facts

Cougars games have finished with more than 133.5 points 14 times so far this year.
Blue Devils games have gone over 133.5 points on 28 occasions this year.
The total for this matchup is 133.5 points, 20.4 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

Houston has won 22 of 26 games when the moneyline favorite this season (84.6%).
Duke has lost both games it has played as underdogs this season.
When playing as a moneyline favorite with odds of -218 or shorter, Houston has gone 20-1 (95.2% win percentage).
Duke has not entered a game this season with longer moneyline odds than +180.

Houston vs. Duke: 2023-24 Stats Comparison

	Houston	Duke
Points Scored Per Game (Rank)	74.1 (155)	79.8 (42)
Points Allowed (Rank)	57.7 (1)	66.5 (30)
Rebounds (Rank)	12.3 (8)	8.9 (150)
3pt Made (Rank)	7.9 (127)	8.4 (79)
Assists (Rank)	13.2 (163)	15.4 (47)
Turnovers (Rank)	8.4 (7)	9.3 (27)

Houston 2023-24 Key Players

Cougars Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
LJ Cryer	36	15.5	2.4	1.9	1.1	0.1	3.1
Jamal Shead	36	13.2	3.8	6.4	2.2	0.5	1.2
Emanuel Sharp	36	12.8	3.6	0.9	1.5	0.1	2.3
J'wan Roberts	35	9.4	6.8	1.9	1.3	0.9	0
Damian Dunn	36	6.5	2.4	0.4	0.8	0.1	0.7

Duke 2023-24 Key Players

Blue Devils Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Kyle Filipowski	34	16.6	8.1	2.9	1.2	1.6	1.1
Jared McCain	34	14	4.9	1.8	1.1	0.1	2.4
Jeremy Roach	33	14	2.5	3.2	1.1	0.1	1.6
Mark Mitchell	31	12.1	6.1	1.1	0.8	0.7	0.4
Tyrese Proctor	30	10.9	3.1	3.8	0.6	0.1	1.9