Creighton vs. DePaul Prediction, How to Watch, Odds, Channel - Feb 25

Published Feb. 24, 2026 8:28 p.m. ET

Data Skrive

The Creighton Bluejays (14-14, 8-9 Big East) host the DePaul Blue Demons (14-13, 6-10 Big East) in a matchup of Big East rivals at CHI Health Center Omaha, tipping off at 9 p.m. ET on Wednesday, February 25, 2026.

The Bluejays are a 5.5-point favorite against the Blue Demons when the Bluejays and the Blue Demons meet. The point total for the game is set at 140.5.

Keep reading to get all the information before wagering on the Creighton-DePaul matchup.

Creighton vs. DePaul How to Watch & Odds

When: Wednesday, February 25, 2026 at 9 p.m. ET
Where: CHI Health Center Omaha in Omaha, Nebraska
TV: Peacock
Live Box Score: FOX Sports

Bluejays vs Blue Demons Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Bluejays	-5.5	-104	-116	140.5	-114	-108	-228	+181

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Creighton vs. DePaul Prediction

Pick ATS: DePaul (+5.5)
Pick OU: Over (140.5)
Prediction: Creighton 76, DePaul 70

Learn more about the Creighton Bluejays vs. the DePaul Blue Demons game on FOX Sports!

Creighton vs. DePaul Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Bluejays 73, Blue Demons 68.
The Bluejays have a 69.5% chance to collect the win in this game based on the moneyline's implied probability.
The Blue Demons sit with a 35.6% implied probability to come out on top.

Key Spread Facts

Creighton has covered nine times in 28 chances against the spread this season.
DePaul has put together a 16-11-0 record against the spread this year.
When playing as at least 5.5-point favorites this season, Creighton has an ATS record of 4-5.
DePaul is 6-4 ATS this season when playing as at least 5.5-point underdogs.

Key Total Facts

Bluejays games have finished with more than 140.5 points 21 times so far this year.
So far this season, 13 Blue Demons games have featured more than 140.5 points scored.
The over/under for this game is 140.5 points, 6.7 fewer than the scoring average of the two teams combined.

Key Moneyline Facts

Creighton has been favored on the moneyline 14 times this season. They've gone 10-4 in those games.
This season, DePaul has won four out of the 15 games, or 26.7%, in which it has been the underdog.
Creighton has won all eight games it played as a moneyline favorite with odds of -228 or shorter.
This season, DePaul has won two of its 10 games, or 20%, when it is the underdog by at least +181 on the moneyline.

Creighton vs. DePaul: Recent Results

Bluejays vs Blue Demons Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
2/11/2026	Bluejays	-1.5	141.5	-115	-107	72-71 DEPAUL
3/13/2025	Bluejays	-12.5	142.5	-943	+613	85-81 CREIGH
2/26/2025	Bluejays	-16.5	147.5	-1818	+976	75-65 CREIGH
1/21/2025	Bluejays	-7	144.5	-297	+237	73-49 CREIGH

Creighton vs. DePaul: 2025-26 Stats Comparison

	Creighton	DePaul
Points Scored Per Game (Rank)	75.7 (189)	71.5 (284)
Points Allowed (Rank)	75.7 (234)	69.8 (73)
Rebounds (Rank)	7.9 (299)	9.0 (197)
3pt Made (Rank)	9.9 (36)	7.3 (231)
Assists (Rank)	15.5 (87)	15.3 (98)
Turnovers (Rank)	10.5 (123)	11.1 (199)

Creighton 2025-26 Key Players

Bluejays Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Josh Dix	28	12.1	3.7	2.5	0.9	0.3	1.8
Austin Swartz	26	10.9	2.6	1.5	0.7	0.2	2.2
Nik Graves	28	10.1	3.0	3.9	0.9	0.1	1.3
Jasen Green	27	10.1	5.6	2.2	0.8	0.7	0.6
Blake Harper	28	8.7	4.0	1.3	0.6	0.1	0.7

DePaul 2025-26 Key Players

Blue Demons Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
CJ Gunn	27	14.0	3.7	2.0	1.1	0.7	1.8
Layden Blocker	27	11.5	2.4	3.5	1.7	0.3	1.1
N.J. Benson	27	11.2	7.3	1.3	0.3	0.7	0.0
Brandon Maclin	24	9.9	4.5	2.6	1.3	0.3	0.7
RJ Smith	27	7.3	2.6	2.5	0.6	0.3	1.3