USC vs. Michigan Prediction, Odds, Picks - September 21, 2024

Updated Sep. 21, 2024 3:07 p.m. ET

Data Skrive

The No. 11 USC Trojans (2-0) are 4.5-point favorites when they visit the No. 18 Michigan Wolverines (2-1) in a Big Ten matchup on Saturday, September 21, 2024 at Michigan Stadium. The point total is set at 44 for the outing.

Against the Utah State Aggies in their most recent contest, the Trojans won 48-0. The Wolverines won against the Arkansas State Red Wolves in their most recent game, 28-18.

Keep up with college football all season on FOX Sports.

Nick says Caleb Williams' reaction to CJ Stroud was justified: 'You're not big bro' | What's Wright?

The Chicago Bears dropped to 0-2 after coming up short 19-13 against the Houston Texans. After the game, CJ Stroud told Caleb Williams "Good job out there' and to "stop taking those hits." He then pulled Williams back as he was walking away and said: "Come here. Learn from those mistakes. And everything that you got, bro, is in you already, bro. You're going to be a hell of a player in this league." Social media focused on Williams' body language and appearance. Nick Wright defends Caleb and explains why his reaction to Stroud's comments was justified.

USC vs. Michigan Game Information & Odds

When: Saturday, September 21, 2024 at 3:30 p.m. ET
Location: Michigan Stadium in Ann Arbor, Michigan
TV: CBS
Live Box Score on FOX Sports

More College Football Predictions

USC vs Michigan Betting Information updated as of September 21, 2024, 2:47 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-4.5 (-110)	-189	+156	44	-111	-109

USC vs. Michigan Prediction

Pick ATS: Michigan (+4.5)
Pick OU: Over (44)
Prediction: Michigan 24, USC 21

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan Wolverines game on FOX Sports!

USC vs. Michigan Betting Insights

Based on the spread and over/under, the implied score for the game is Trojans 24, Wolverines 20.
The Trojans have a 65.4% chance to collect the win in this game per the moneyline's implied probability. The Wolverines hold a 39.1% implied probability.
USC has covered twice in two games with a spread this season.
Michigan has put together a 0-3-0 record against the spread this season.

USC vs. Michigan: 2024 Stats Comparison

	USC	Michigan
Off. Points per Game (Rank)	37.5 (83)	23.3 (91)
Def. Points per Game (Rank)	10 (10)	19.7 (60)
Turnovers Allowed (Rank)	1 (6)	7 (120)
Turnovers Forced (Rank)	2 (98)	3 (69)

USC 2024 Key Players

Name	Position	Stats
Jo'Quavious Marks	RB	171 YDS / 3 TD / 85.5 YPG / 5.9 YPC 6 REC / 46 REC YDS / 0 REC TD / 23 REC YPG
Miller Moss	QB	607 YDS (72.7%) / 2 TD / 0 INT
Quinten Joyner	RB	96 YDS / 2 TD / 48 YPG / 6.9 YPC
Ja'Kobi Lane	WR	5 REC / 66 YDS / 1 TD / 33 YPG
Kamari Ramsey	DB	10 TKL / 0 TFL / 1 SACK
Eric Gentry	LB	7 TKL / 3 TFL / 1 SACK
Mason Cobb	LB	4 TKL / 0 TFL / 1 INT / 1 PD
Easton Mascarenas	LB	5 TKL / 0 TFL / 1 INT / 1 PD

Michigan 2024 Key Players

Name	Position	Stats
Kalel Mullings	RB	270 YDS / 2 TD / 90 YPG / 7.5 YPC
Donovan Edwards	RB	150 YDS / 1 TD / 50 YPG / 4.2 YPC 4 REC / 13 REC YDS / 1 REC TD / 4.3 REC YPG
Colston Loveland	TE	19 REC / 187 YDS / 1 TD / 62.3 YPG
Alex Orji	QB	15 YDS (50%) / 2 TD / 0 INT 58 RUSH YDS / 0 RUSH TD / 19.3 RUSH YPG
Josaiah Stewart	DL	6 TKL / 3 TFL / 2 SACK
Ernest Hausmann	LB	11 TKL / 1 TFL / 1 SACK
Rayshaun Benny	DL	8 TKL / 2 TFL / 1 SACK
Makari Paige	DB	9 TKL / 0 TFL / 1 INT / 1 PD