National Football League

NFL odds: How to bet Packers vs. Cardinals, point spread, more

Updated Oct. 28, 2021 6:44 p.m. ET

The Green Bay Packers (6-1) are already facing a battle even before Thursday night's big showdown against the Arizona Cardinals (7-0) in a matchup between the teams with the two longest active winning streaks in the NFL (Cardinals seven straight, Packers six in a row).

Here's everything you need to know about the NFL odds on Thursday's matchup between the Packers and Cardinals — the point spread, moneyline and total over/under (with all NFL odds via FOX Bet).

GREEN BAY PACKERS @ ARIZONA CARDINALS (8:20 p.m. ET Thursday, FOX)

Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 or more points, otherwise Packers cover)
Moneyline: Cardinals -278 favorites to win (bet $10 to win $13.60 total); Packers +225 underdogs to win (bet $10 to win $32.50 total)
Total scoring over/under: 50.5 points scored by both teams combined

Quarterback Aaron Rodgers and the vaunted Packers passing attack will be missing a few key receivers for the big game. Green Bay is also expected to be without its defensive coordinator Joe Barry on Thursday.

More importantly, Green Bay placed Davante Adams – Rodgers' favorite target – on the reserve/COVID-19 list Monday after the receiver reportedly tested positive for COVID-19. Adams reportedly has not cleared protocols and will not play Thursday, according to reports.

Adams is tied for second in the NFL in receptions (52) and third in receiving yards (744). He also leads the Packers in catches (52), receiving yards (744), and is tied for second in the NFL in catches and third in yards among all receivers.

One thing to keep in mind, Green Bay is 6-0 without Adams the past two seasons. The Packers have won twice this season without Adams and four times last season.

On Tuesday, the Packers also placed WR Allen Lazard on the reserve/COVID-19 list. He'll also miss Thursday's game.

The Packers will also be without receiver Marquez Valdes-Scantling, who has missed four games with a hamstring injury.

On the Arizona side, the Cardinals activated pass-rusher Chandler Jones, who is second on the team with five sacks, and defensive lineman Zach Allen from the reserve/COVID-19 list Monday.

On the flip side, star defensive player J.J. Watt has suffered a potentially season-ending shoulder surgery. Thus, Watt will miss tonight's big matchup.

Stats and Trends

The Packers lead the all-time series 45-26-4.

The Cardinals have won three straight games vs. Green Bay and four of their past five matchups, including two playoff wins (2010 wild card game 51-45, and 2016 divisional round 26-20).

Arizona has won three in a row at home against Green Bay.

The Cardinals are 5-0 against the spread (ATS) in their past five games.

Arizona QB Kyler Murray has thrown at least three passing touchdowns in a game four times this season.

Rodgers is 8-4 on Thursday night starts with 27 touchdown passes, five interceptions, and a 105.5 passer rating.

So who has the edge in this week's edition of Thursday Night Football?

Picks via FOX Sports' Geoff Schwartz: "Without Adams and Lazard, Aaron Jones will become the focal point of this offense. The Cardinals are allowing 5 yards a rush, good for 31st in the NFL. It has not hurt them because they've been ahead in most games, so teams stop rushing the football.

"The Packers are not a team that would abandon their game plan early if behind. The Packers stay in this game with Jones being a huge part of this offense."

PICK: Aaron Jones 50+ rushing yards and to score a touchdown (+137 at FOX Bet)

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Picks via FOX Sports' Jason McIntyre: "The narrative is that this will be a high-scoring game, and the market agrees, as Kyler Murray's passing yards total has continued to soar. I'll go counter to that. Give me the James Conner rushing yards over. Green Bay's run defense is putrid, giving up 4.9 yards per play (ypp), ranking 30th in the NFL.

"If you're looking for a Packers play, Aaron Jones receiving yards may be worth a look, because make no mistake, he's their best-receiving option tonight. Green Bay's strategy will be to play keep-away from the Cardinals' high-powered offense (6.1 ypp, seventh in the NFL). And Arizona's been run over a couple of times this season, ranking 31st in rushing defense on a yards per carry basis (5.0)."

PICK: James Conner OVER 46.5 rushing yards at FOX Bet

PICK: Aaron Jones OVER 38.5 receiving yards at FOX Bet

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