UCLA vs. Southern Prediction, Odds, Picks – Women's Basketball NCAA Tournament First Round 2025

An opening-round NCAA Tournament matchup will see the 16th-seeded Southern Jaguars (21-14) hit the court as 41.5-point underdogs against the No. 1 seed UCLA Bruins (30-2) on Friday at Pauley Pavilion. The contest begins at 10 p.m. ET on ESPN. Here's what you need to know when filling out your brackets for this 1-16 matchup. The matchup has an over/under of 121.5.

UCLA vs. Southern Game Info

• Game day: Friday, March 21, 2025
• Game time: 10 p.m. ET
• TV channel: ESPN
• Follow this game live on FOX Sports

UCLA vs. Southern Odds

UCLA vs. Southern Prediction

• Computer Pick ATS: Southern (+41.5)
  
• Computer Pick OU: Over (121.5)
  
• Computer Prediction: UCLA 79, Southern 47

Learn more about the UCLA Bruins vs. the Southern Jaguars game on FOX Sports!

UCLA Betting Insights

• The Bruins have 15 wins in 32 games against the spread this season.
• UCLA doesn't have a win ATS (0-2) as a 41.5-point favorite or greater this season.
• Out of 32 Bruins games so far this year, 16 have hit the over.

Southern Betting Insights

• The Jaguars have beaten the spread six times in seven games.
• Southern is winless ATS (0-1) when playing as at least a 41.5-point underdog this season.
• The Jaguars have seen five of their seven games hit the over.

UCLA's Top Performers

Southern's Top Performers

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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