The Biggest NFL Upsets in Week 5 - 2025

The Biggest NFL Upsets in Week 5 - 2025

Updated Oct. 9, 2025 6:33 p.m. ET
Data Skrive

You want upsets? We've got upsets. Multiple underdogs took down the favorite in Week 5 of the 2025 NFL season. Keep reading to find a complete list of the teams that defied the odds.

Read more about last week's NFL games on FOX Sports!

NFL Week 5's Biggest Upsets

49ers 26, Rams 23

  • Spread: Rams -8.5
  • Total: Over (43.5)
  • Moneyline: Rams -450, 49ers +350

Patriots 23, Bills 20

  • Spread: Bills -8
  • Total: Under (49.5)
  • Moneyline: Bills -450, Patriots +350

Titans 22, Cardinals 21

  • Spread: Cardinals -7.5
  • Total: Over (41.5)
  • Moneyline: Cardinals -400, Titans +325

Broncos 21, Eagles 17

  • Spread: Eagles -4
  • Total: Under (44)
  • Moneyline: Eagles -225, Broncos +185

Jaguars 31, Chiefs 28

  • Spread: Chiefs -3.5
  • Total: Over (45.5)
  • Moneyline: Chiefs -200, Jaguars +165

Buccaneers 38, Seahawks 35

  • Spread: Seahawks -3.5
  • Total: Over (44.5)
  • Moneyline: Seahawks -190, Buccaneers +155

Commanders 27, Chargers 10

  • Spread: Chargers -3
  • Total: Under (47.5)
  • Moneyline: Chargers -165, Commanders +140

Panthers 27, Dolphins 24

  • Spread: Dolphins -1
  • Total: Over (44.5)
  • Moneyline: Dolphins -118, Panthers -102

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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