The Biggest NFL Upsets in Week 5 - 2025

You want upsets? We've got upsets. Multiple underdogs took down the favorite in Week 5 of the 2025 NFL season. Keep reading to find a complete list of the teams that defied the odds.

Read more about last week's NFL games on FOX Sports!

NFL Week 5's Biggest Upsets

49ers 26, Rams 23

• Spread: Rams -8.5
• Total: Over (43.5)
• Moneyline: Rams -450, 49ers +350

Patriots 23, Bills 20

• Spread: Bills -8
• Total: Under (49.5)
• Moneyline: Bills -450, Patriots +350

Titans 22, Cardinals 21

• Spread: Cardinals -7.5
• Total: Over (41.5)
• Moneyline: Cardinals -400, Titans +325

Broncos 21, Eagles 17

• Spread: Eagles -4
• Total: Under (44)
• Moneyline: Eagles -225, Broncos +185

Jaguars 31, Chiefs 28

• Spread: Chiefs -3.5
• Total: Over (45.5)
• Moneyline: Chiefs -200, Jaguars +165

Buccaneers 38, Seahawks 35

• Spread: Seahawks -3.5
• Total: Over (44.5)
• Moneyline: Seahawks -190, Buccaneers +155

Commanders 27, Chargers 10

• Spread: Chargers -3
• Total: Under (47.5)
• Moneyline: Chargers -165, Commanders +140

Panthers 27, Dolphins 24

• Spread: Dolphins -1
• Total: Over (44.5)
• Moneyline: Dolphins -118, Panthers -102

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

FOLLOW Follow your favorites to personalize your FOX Sports experience

National Football League