Seahawks vs. Cardinals 2025 Prediction, Odds, Picks - Nov 9

Having won three in a row, the Seattle Seahawks (6-2) will face the Arizona Cardinals (3-5). The Seahawks are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6.5). The game has an over/under of 45.5 points.

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Seahawks vs. Cardinals Odds & Betting Lines

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Seahawks vs. Cardinals Prediction & Pick

• Pick ATS: Seahawks (-6.5)
  
• Pick OU: Over (45.5)
  
• Prediction: Seahawks 31 - Cardinals 15

How to Watch Seattle vs. Arizona

• Game date: Sunday, November 9, 2025
• Time: 4:05 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: CBS
• Live Boxscore: FOX Sports

Seahawks vs. Cardinals Recent Matchups

• In their past five head-to-head meetings, Seattle has taken down Arizona five times.
• Over their last five head-to-head contests, Seattle has scored 110 points, while Arizona has posted 74.

Seattle Betting Info

• Seattle has played eight games, posting six wins against the spread.
• The Seahawks have covered the spread when playing as at least 6.5-point favorites in their only opportunity this season.
• Seattle has combined with its opponent to gone over the point total in 62.5% of its contests this year (five times over eight games with a set point total).
• The Seahawks have compiled a 5-1 record in games they played as the moneyline favorite (winning 83.3% of those games).
• Looking at this game's moneyline, the Seahawks' implied win probability is 77.3%.

Seahawks Stats

Seattle's Key Players

Offense

• Sam Darnold has 2,084 passing yards (eighth in the NFL), 16 touchdowns (ninth in the NFL) and five interceptions this year. He has completed 70.4% of his attempts, averaging 260.5 yards per game and 9.6 per attempt.
• Jaxon Smith-Njigba's 948 receiving yards this season (first in the NFL) have come from 79 targets and 58 receptions (fifth in the NFL). He's averaging 118.5 receiving yards and 7.3 catches per game, with four receiving touchdowns.
• Kenneth Walker III's output on the ground this season includes 472 yards and three TDs. He is averaging 59 yards per game and 4.5 per attempt (21st in the NFL).
• Rashid Shaheed averages 4.9 receptions and 55.4 yards per game, and has 499 total receiving yards and 44 catches. He's gotten 66 total targets, and has caught two touchdown passes.

Defense

• On defense for the Seahawks, Ernest Jones has racked up 65 tackles, three TFL, 0.5 sacks, and three interceptions in 2025.
• Drake Thomas has 34 tackles, six TFL, and three sacks this season.
• Leonard Williams has recorded 35 tackles, four TFL, and four sacks this year.
• Byron Murphy has five sacks (second on the Seahawks) in addition to his four TFL and 33 tackles this year.

Arizona Betting Info

• Arizona is 5-3-0 against the spread this year.
• The Cardinals have always covered the spread this year when underdogs by 6.5 points or more.
• This year, Arizona games have hit the over four times.
• This season, the Cardinals have been the underdog five times and won one of those games.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 27.0% chance to win.

Cardinals Stats

Arizona's Key Players

Offense

• Trey McBride has registered 476 receiving yards and five touchdowns (10th in the NFL) on 52 receptions (eighth in the NFL), while being targeted 75 times this season.
• Marvin Harrison Jr. has 492 receiving yards and three touchdowns on 31 receptions, while being targeted 50 times.
• Through five games this season, Jacoby Brissett has amassed 860 passing yards, while throwing six touchdowns against one interception and completing 65.2% of his attempts.
• Brissett has also rushed for one touchdown and 51 yards (seventh on the Cardinals).
• Bam Knight has scored two touchdowns on the ground, while running for 129 total yards (3.4 per carry and 21.5 per game).

Defense

• So far in 2025, Mack Wilson has amassed 60 tackles, three TFL, and one interception over eight games.
• Josh Sweat's stats include 17 tackles, nine TFL, seven sacks, and two passes defended.
• During the 2025 season, Akeem Davis-Gaither has 44 tackles and one TFL in eight games.
• Calais Campbell's stat sheet includes 21 tackles, seven TFL, five sacks, and one pass defended in eight games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Seattle Seahawks

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