Rams vs. Jaguars 2025 Prediction, Odds, Picks - Oct 19

This week, the NFL travels to London, England as the Los Angeles Rams (4-2) play the Jacksonville Jaguars (4-2) at Wembley Stadium on Sunday, October 19, 2025. The Rams are favorites in this one, with the spread sitting at 3 points. The predicted point total for the matchup is 45.5.

Keep up with the 2025 NFL season on FOX Sports.

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Rams vs. Jaguars Odds & Betting Lines

Rams vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+3)
  
• Pick OU: Under (45.5)
  
• Prediction: Rams 22 - Jaguars 20

How to Watch Los Angeles vs. Jacksonville

• Game date: Sunday, October 19, 2025
• Time: 9:30 a.m. ET
• Venue: Wembley Stadium
• Location: London, England
• TV: NFL Network
• Live Boxscore: FOX Sports

Rams vs. Jaguars Recent Matchups

• Los Angeles owns a 2-0 record against Jacksonville in their last two matchups.
• In their last two head-to-head matchups, Los Angeles has racked up 64 points versus Jacksonville, while giving up only 24 points.

Los Angeles Betting Info

• Los Angeles is 4-2-0 against the spread this year.
• The Rams have been favored by 3 points or more five times this season, and covered the spread in four of those contests.
• Los Angeles games in 2025 have gone over the point total three times in six opportunities (50%).
• When playing as the moneyline favorite, the Rams are 4-1, earning a victory 80% of the time.
• Based on this contest's moneyline, the Rams' implied win probability is 62.4%.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford ranks first in the NFL with 1,684 passing yards in six games this year, averaging 280.7 per game with a 66.5% completion percentage and 12 touchdowns (fourth in the NFL) against two interceptions.
• Puka Nacua's 616 receiving yards this season (third in the NFL) have come from 65 targets and 54 receptions (second in the NFL). He's averaging 102.7 receiving yards and 9.0 catches per game, with two receiving touchdowns.
• Kyren Williams' output on the ground this season includes 418 yards (10th in the NFL) and two TDs. He is averaging 69.7 yards per game and 4.4 per attempt (21st in the NFL).
• Williams has been on the receiving end of 23 targets in the passing game and has 18 catches (3.0 per game) for 155 yards (25.8 per game) and three TDs.
• Davante Adams has 26 catches for 396 yards and three touchdowns. He's been targeted 55 times in the air attack, and averages 4.3 receptions and 66.0 yards in six games played.

Defense

• On defense, Byron Young has 37 tackles, 9.0 TFL, and 7.5 sacks in 2025.
• Jared Verse has 29 tackles, 6.0 TFL, and three sacks this season.
• Nathan Landman has recorded 58 tackles and 1.0 TFL this year. His tackle total leads the Rams and is fourth in the NFL.
• Kamren Curl has two interceptions (sixth in the NFL) while also adding 47 tackles, 2.0 TFL, one sack, and three passes defended.

Jacksonville Betting Info

• Jacksonville is 4-2-0 against the spread this season.
• The Jaguars have been underdogs by 3 points or more three times this season and have covered the spread twice.
• This year, Jacksonville games have hit the over three times.
• This season, the Jaguars have won two out of the four games in which they've been the underdog.
• The oddsmakers' moneyline implies a 41.7% chance of a victory for the Jaguars.

Jaguars Stats

Jacksonville's Key Players

Offense

• In six games played this year, Trevor Lawrence has racked up 1,324 passing yards, with eight touchdowns against five interceptions and completing 61.1% of his attempts.
• Lawrence has also rushed for two touchdowns and 95 yards (third on the Jaguars).
• Travis Etienne has 470 rushing yards (leading the Jaguars and sixth in the NFL) and two rushing touchdowns, while averaging 78.3 yards per game and 5.3 per attempt (seventh in the NFL).
• Etienne has added 13 receptions (2.2 per game) for 69 yards (11.5 per game) with one receiving touchdown. He's been targeted 19 times in the passing game.
• Brian Thomas has totaled 334 receiving yards and one touchdown on 24 receptions, while being targeted 48 times on the season.
• Bhayshul Tuten averages 18.0 rushing yards per game through six games (108 total yards), with one rushing touchdown.
• Tuten also has 59 receiving yards (9.8 per game) on six catches (1.0 per game). He has been targeted eight times with one touchdown reception.

Defense

• Foyesade Oluokun's 2025 effort includes 53 tackles, 3.0 TFL, one sack, and one interception through six games. He leads the Jaguars and is eighth in the NFL in tackles.
• Devin Lloyd has 22 tackles, 2.0 TFL, and four interceptions.
• Jourdan Lewis has intercepted two passes on top of 23 tackles, 4.0 TFL, and seven passes defended in the 2025 campaign. His interception total ranks sixth in the league.
• Andrew Wingard's stats include one interception as well as 34 tackles and two passes defended in six games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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