Rams vs. Cardinals 2025 Prediction, Odds, Picks - Dec 7

Having lost one in a row, the Arizona Cardinals (3-9) will face the Los Angeles Rams (9-3). The Rams are solid favorites, expected to win by at least a touchdown (currently -8.5). The over/under for this one is set at 47.5 points.

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Rams vs. Cardinals Odds & Betting Lines

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Rams vs. Cardinals Prediction & Pick

• Pick ATS: Rams (-8.5)
  
• Pick OU: Under (47.5)
  
• Prediction: Rams 31 - Cardinals 15

How to Watch Los Angeles vs. Arizona

• Game date: Sunday, December 7, 2025
• Time: 4:25 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Rams vs. Cardinals Recent Matchups

• In their past five head-to-head contests, Los Angeles has beaten Arizona three times.
• Over their last five head-to-head contests, Los Angeles has racked up 103 points, while Arizona has compiled 100.

Los Angeles Betting Info

• Los Angeles has eight wins in 12 games versus the spread this season.
• The Rams have been favored by 8.5 points or more three times this season, and covered the spread in one of those matchups.
• Los Angeles games this year have hit the over on five of 12 set point totals (41.7%).
• When playing as moneyline favorites, the Rams are 9-2, earning a victory 81.8% of the time.
• The Rams have an 82.0% chance to win this matchup, based on the implied probability of the moneyline.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford has 3,073 passing yards (fifth in the NFL), 32 touchdowns (first in the NFL) and four interceptions this year. He has completed 66.3% of his attempts, averaging 256.1 yards per game and 7.7 per attempt.
• Kyren Williams' rushing statline this season includes 868 yards (ninth in the NFL) and seven TDs. He's averaging 72.3 yards per game and 4.7 per attempt (13th in the NFL).
• Williams has 24 receptions on 33 targets for 184 yards. He has three receiving TDs.
• Davante Adams has 14 touchdown catches this season (first in the NFL), and has 52 catches for 689 yards on 99 targets, while averaging 4.3 catches and 57.4 yards per game.
• Puka Nacua has 86 receptions (second in the NFL) for 1,019 yards (third in the NFL) and four touchdowns. He's been targeted 107 times in the passing game, and averages 7.8 receptions and 92.6 yards through 11 games played.

Defense

• On defense for the Rams, Nathan Landman has powered the unit with 106 tackles, 5.0 TFL, and 1.5 sacks in 2025.
• Byron Young has 61 tackles, 10.0 TFL, and 10 sacks this season. He's third on the Rams in tackles.
• Kamren Curl has recorded 91 tackles, 2.0 TFL, one sack, and two interceptions this year.
• So far this season, Jared Verse has 44 tackles, 9.0 TFL, and six sacks.

Arizona Betting Info

• Arizona is 6-6-0 against the spread this year.
• The Cardinals have been underdogs by 8.5 points or more once this year and covered the spread.
• This season, Arizona games have hit the over seven times.
• The Cardinals have won one of the nine games they've played as underdogs this season.
• The oddsmakers' moneyline implies a 22.2% chance of a victory for the Cardinals.

Cardinals Stats

Arizona's Key Players

Offense

• Jacoby Brissett is averaging 7.2 passing yards per attempt (13th in the NFL) and 243.1 yards per game this year, completing 67.5% of his passes on the way to 2,188 total yards, 13 touchdowns and four interceptions through nine games.
• He's added 116 yards on the ground (sixth on the Cardinals), with one rushing touchdown. He's averaging 12.9 yards per game and 4.3 per attempt.
• Trey McBride has put together a 2025 stat sheet that includes 88 catches (first in the NFL) for 879 yards (sixth in the NFL) and eight receiving touchdowns (third in the NFL) over 12 games played. He has been on the receiving end of 118 targets and is averaging 7.3 receptions per game.
• So far this season, Marvin Harrison Jr. has caught 40 passes for 594 receiving yards with four touchdowns through the air. He has been targeted 69 total times and is averaging 4.0 receptions per game through 10 games played.
• Bam Knight has scored four touchdowns on the ground, while running for 255 total yards (3.4 per attempt and 25.5 per game).
• Knight also has 142 receiving yards (14.2 per game) on 19 catches (1.9 per game). He has been targeted 25 times with one touchdown reception.

Defense

• In 2025, Josh Sweat has amassed 11.0 sacks to go with 12.0 TFL and 25 tackles over 12 games. He ranks fourth in the NFL in sacks.
• Akeem Davis-Gaither has one interception on top of 68 tackles, 2.0 TFL, and four passes defended.
• In the 2025 season, Budda Baker has 87 tackles, 2.0 TFL, 0.5 sacks, and one interception in 12 games.
• Jalen Thompson's stat sheet includes 74 tackles, 2.0 TFL, one sack, and six passes defended in 12 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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