Lions vs. Bengals 2025 Prediction, Odds, Picks - Oct 5

The Detroit Lions (3-1) will be trying to continue a three-game winning run against the Cincinnati Bengals (2-2). The Lions are solid favorites, expected to win by at least a touchdown (currently -9.5). An over/under of 49.5 points has been established for the matchup.

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Lions vs. Bengals Odds & Betting Lines

Lions vs. Bengals Prediction & Pick

• Pick ATS: Lions (-9.5)
  
• Pick OU: Over (49.5)
  
• Prediction: Lions 32 - Bengals 18

How to Watch Detroit vs. Cincinnati

• Game date: Sunday, October 5, 2025
• Time: 4:25 p.m. ET
• Venue: Paycor Stadium
• Location: Cincinnati, Ohio
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Lions vs. Bengals Recent Matchups

• In their past two head-to-head matchups, Cincinnati has defeated Detroit two times.
• Detroit has been outscored by 32 points in its last two tilts versus Cincinnati.

Detroit Betting Info

• Against the spread, Detroit is 3-1-0 this season.
• Detroit games this year have hit the over on two of four set point totals (50%).
• The Lions have been moneyline favorites in two other games this season, and they won both.
• The implied probability for this matchup, considering the moneyline, gives the Lions an 85.2% chance to win.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff has 929 passing yards (10th in the NFL), nine touchdowns (third in the NFL) and two interceptions this year. He has completed 73.8% of his attempts, averaging 232.3 yards per game and 7.6 per attempt.
• Amon-Ra St. Brown has caught 27 passes (fourth in the NFL) on 32 targets for 307 total yards (ninth in the NFL) and six touchdowns. He is averaging 6.8 catches and 76.8 yards per game through four games.
• Jahmyr Gibbs' output on the ground this season includes 271 yards and four TDs. He's averaging 67.8 yards per game and 4.7 per attempt (18th in the NFL).
• Gibbs has totaled 20 receptions on 21 targets for 79 yards, though he has not scored a receiving touchdown.
• David Montgomery has rushed for 245 yards with three touchdowns (61.3 yards per game through four games).

Defense

• On the defensive side, Jack Campbell has 35 tackles, 2.0 TFL, and one sack in 2025. His tackle total leads the Lions.
• Brian Branch has 22 tackles, 4.0 TFL, and one sack this season. He's third on the Lions in tackles.
• Aidan Hutchinson has recorded eight tackles, 4.0 TFL, and four sacks.
• This season, Al-Quadin Muhammad has seven tackles, 3.0 TFL, and 3.5 sacks.

Cincinnati Betting Info

• Cincinnati has covered the spread one time in four games with a set spread.
• Cincinnati games have gone over the total twice this year.
• The Bengals have lost both games they've played as underdogs this season.
• The oddsmakers' moneyline implies a 19.0% chance of a victory for the Bengals.

Bengals Stats

Cincinnati's Key Players

Offense

• Ja'Marr Chase has put up 264 receiving yards and one touchdown on 26 receptions (sixth in the NFL), while being targeted 35 times this season.
• Through three games, Jake Browning has 506 passing yards, with three touchdowns against five interceptions and completing 64.3% of his attempts.
• Browning also has one rushing touchdown and 8 rushing yards (fifth on the Bengals).
• Chase Brown has rushed for one touchdown this year, and has totaled 133 rushing yards (33.3 per game and 2.3 per attempt).
• Brown's statistic output includes 11 receptions (2.8 per game) on 14 targets for 74 yards (18.5 per game), but he has not scored a touchdown in the passing game.
• Tee Higgins has been targeted 20 times, resulting in 10 catches for 136 yards .

Defense

• Jordan Battle's 2025 effort includes 32 tackles and two interceptions in four games. He leads the Bengals in tackles.
• Daxton Hill has 28 tackles, 1.0 TFL, and one interception. He is third on the Bengals in tackles.
• Demetrius Knight II has 31 tackles and one interception.
• Trey Hendrickson has totaled 2.0 sacks (first on the Bengals) as well as 2.0 TFL and 11 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cincinnati Bengals

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