Jaguars vs. Texans 2025 Prediction, Odds, Picks - Sep 21

In a battle of two division rivals, the Jacksonville Jaguars (1-1) will face off against the Houston Texans (0-2). The Jaguars are small favorites (-1.5). An over/under of 43.5 points has been set for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

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Jaguars vs. Texans Odds & Betting Lines

Jaguars vs. Texans Prediction & Pick

• Pick ATS: Texans (+1.5)
  
• Pick OU: Over (43.5)
  
• Prediction: Texans 25 - Jaguars 18

How to Watch Jacksonville vs. Houston

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: CBS
• Live Boxscore: FOX Sports

Jaguars vs. Texans Recent Matchups

• Houston owns a 3-2 record against Jacksonville in their last five matchups.
• Over their last five head-to-head contests, Jacksonville has scored 112 points, while Houston has accumulated 108.

Jacksonville Betting Info

• Jacksonville has covered the spread one time this season.
• The Jaguars have won their only game this season when playing as at least 1.5-point favorites.
• Jacksonville games this year have gone over the total in one out of two opportunities (50%).
• The Jaguars have been moneyline favorites a single other time this season, a game they won.
• The Jaguars have an implied win probability, based on the moneyline, of 55.6%.

Jaguars Stats

Jacksonville's Key Players

Offense

• Travis Etienne's rushing stat line this season includes 214 yards (third in the NFL) but no touchdowns. He's averaging 107.0 yards per game and 7.1 per attempt (second in the NFL).
• He's also caught five passes (on six targets) for 31 receiving yards with one touchdown. He's averaging 15.5 receving yards and 2.5 catches per game.
• Trevor Lawrence has 449 passing yards, four touchdowns (eighth in the NFL) and three interceptions this year. He has completed 58.9% of his attempts, averaging 224.5 yards per game and 6.2 per attempt.
• In the passing game, Dyami Brown, has racked up 109 receiving yards and one touchdown after pulling down eight balls on 11 targets. Per game, he's averaging 54.5 yards and 4.0 receptions through two games.
• Bhayshul Tuten has rushed for 53 yards without a TD on the ground (26.5 yards per game in two games).
• He has added two catches (on two targets) for 32 receiving yards with one touchdown. He's averaging 16.0 receiving yards and 1.0 receptions per game.

Defense

• On defense, Foyesade Oluokun has 17 tackles, 2.0 TFL, one sack, and one interception in 2025. His tackle total leads the Jaguars.
• Jourdan Lewis has 13 tackles, 2.0 TFL, and one interception this season.
• Eric Murray has totaled 13 tackles and one interception this year.
• Tyson Campbell has 1.0 TFL and 11 tackles this year.

Houston Betting Info

• Houston is winless against the spread this season (0-2-0).
• The Texans have been underdogs by 1.5 points or more one time this year and have not covered the spread once.
• Games involving Houston have yet to hit the over once this season.
• The Texans lost the only game they've played as the underdog this season.
• The bookmakers' moneyline implies a 48.8% chance of a victory for the Texans.

Texans Stats

Houston's Key Players

Offense

• C.J. Stroud has passed for 395 yards this year, with one touchdown and one interception. He is completing 62.7% of his passes while averaging 197.5 yards per game and 7.7 per attempt.
• On the ground, Stroud has added 59 rushing yards (second on the Texans).
• Nick Chubb has scored one rushing touchdown, while totaling 103 rushing yards (4.1 per carry and 51.5 per game).
• Chubb has also collected 29 receiving yards (14.5 per game) on two catches (1.0 per game). He's been targeted three times and is still seeking his first receiving touchdown.
• Nico Collins has recorded 77 receiving yards and one touchdown on six receptions, while being targeted 14 times on the season.
• Xavier Hutchinson has four catches for 59 yards without a receiving touchdown. He averages 2.0 yards per game through two games and has been targeted five times.

Defense

• Danielle Hunter has eight tackles, 2.0 TFL, and two sacks in 2025.
• Will Anderson Jr. has 2.0 sacks in addition to his 4.0 TFL and eight tackles through two games. He's ninth in the NFL in sacks.
• Henry To'oTo'o has recorded 1.0 sack (third on the Texans) as well as 2.0 TFL and 17 tackles in the 2025 campaign.
• Azeez Al-Shaair has 17 tackles and one pass defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Jacksonville Jaguars

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