Falcons vs. Panthers 2025 Prediction, Odds, Picks - Sep 21

In a battle of two division rivals, the Atlanta Falcons (1-1) will face off against the Carolina Panthers (0-2). The Falcons are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). An over/under of 44.5 points has been set for the matchup.

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Falcons vs. Panthers Odds & Betting Lines

Falcons vs. Panthers Prediction & Pick

• Pick ATS: Falcons (-4.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Falcons 29 - Panthers 21

How to Watch Atlanta vs. Carolina

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: Bank of America Stadium
• Location: Charlotte, North Carolina
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Falcons vs. Panthers Recent Matchups

• Carolina owns a 3-2 record against Atlanta in their last five matchups.
• Over their last five head-to-head matchups, Atlanta has put up 122 points, while Carolina has accumulated 108.

Atlanta Betting Info

• Atlanta has covered the spread once this season.
• Atlanta games this year have not gone over the total in two opportunities.
• The Falcons have not yet played as the moneyline favorite this season.
• The Falcons have a 69.2% chance to win this game, based on the implied probability of the moneyline.

Falcons Stats

Atlanta's Key Players

Offense

• Bijan Robinson's rushing stat line this season includes 167 yards (fifth in the NFL) but no touchdowns. He is averaging 83.5 yards per game and 4.9 per attempt (11th in the NFL).
• Robinson has 12 targets, nine receptions, 125 receiving yards and one TD through the air.
• Michael Penix Jr. has thrown for 433 yards, one touchdown and zero interceptions this year. He averages 216.5 yards per game and 6.9 per attempt, while completing 63.5%.
• He has tacked on 20 rushing yards (10.0 per game) and one touchdown on the ground.
• Tyler Allgeier's output on the ground this season includes 100 yards and one TD. He's averaging 50.0 yards per game and 3.8 per attempt (24th in the NFL).
• Kyle Pitts averages 5.5 receptions and 48.0 yards per game, and has 96 total receiving yards and 11 catches. He's gotten 13 total targets, but has yet to record a touchdown pass.

Defense

• Over on the defensive side, Zach Harrison has seven tackles, 1.0 TFL, and 1.5 sacks in 2025.
• Billy Bowman has intercepted one pass (third in the NFL) and added 10 tackles, 0.5 sacks, and two passes defended.
• This season, Divine Deablo has recorded 0.5 sacks (fifth on the Falcons) in addition to his 1.0 TFL and 10 tackles.
• So far this season, Xavier Watts has eight tackles and one interception.

Carolina Betting Info

• Carolina has covered the spread once in two games with a set spread.
• The Panthers have covered the spread once this year when underdogs by 4.5 points or more (in two chances).
• Carolina games have gone over the total once this year.
• The Panthers have lost both games they've played as underdogs this season.
• The implied probability of a win by the Panthers based on the moneyline is 35.1%.

Panthers Stats

Carolina's Key Players

Offense

• Bryce Young is averaging 5.4 passing yards per attempt (30th in the NFL) and 241.0 yards per game this year, completing 58.9% of his passes on the way to 482 total yards, four touchdowns (eighth in the NFL) and three interceptions through two games.
• Young has also rushed for 42 yards (second on the Panthers).
• Chuba Hubbard is still looking for a rushing touchdown, while totaling 95 rushing yards (3.7 per attempt and 47.5 per game).
• Hubbard has also picked up 71 receiving yards (35.5 per game) on eight catches (4.0 per game). He's been targeted 11 times and has caught two touchdown passes.
• This season, Hunter Renfrow has caught nine passes for 59 receiving yards with two touchdowns in the passing game (fifth in the NFL). He has been targeted 15 total times and is averaging 4.5 receptions per game through two games played.
• Tetairoa McMillan has been targeted 19 times, resulting in 11 catches for 168 yards (ninth in the NFL) and zero receiving touchdowns.

Defense

• Tre'von Moehrig's 2025 output includes 20 tackles in two games. He leads the Panthers and is eighth in the NFL in tackles.
• Christian Rozeboom has 15 tackles. He is second on the Panthers in tackles.
• D.J. Wonnum has intercepted one pass on top of four tackles, 1.0 TFL, and two passes defended in the 2025 campaign. His interception total ranks third in the league.
• Derrick Brown has seven tackles and two passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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