Falcons vs. Cardinals 2025 Prediction, Odds, Picks - Dec 21

Having lost six in a row, the Arizona Cardinals (3-11) will play the Atlanta Falcons (5-9). The Falcons are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3). The expected point total for the matchup is set at 48.5.

Keep up with the 2025 NFL season on FOX Sports.

Falcons vs. Cardinals Odds & Betting Lines

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Falcons vs. Cardinals Prediction & Pick

• Pick ATS: Cardinals (+3)
  
• Pick OU: Under (48.5)
  
• Prediction: Cardinals 24 - Falcons 23

How to Watch Atlanta vs. Arizona

• Game date: Sunday, December 21, 2025
• Time: 4:05 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Falcons vs. Cardinals Recent Matchups

• The last four times Arizona and Atlanta have squared off, the two teams share the same 2-2 record.
• In their last four head-to-head matchups, Atlanta has compiled 116 points against Arizona, while allowing only 92 points.

Atlanta Betting Info

• Against the spread, Atlanta is 7-7-0 this season.
• The Falcons have not covered the spread when favored by 3 points or more this season (in four opportunities).
• Atlanta games this year have gone over the total in seven out of 14 opportunities (50%).
• When playing as moneyline favorites, the Falcons are 1-4 (winning 20% of the time).
• Looking at this game's moneyline, the Falcons' implied win probability is 60.8%.

Falcons Stats

Atlanta's Key Players

Offense

• On the ground, Bijan Robinson averages 5.0 yards per attempt (eighth in the NFL) and 83.9 yards per game for 1,174 total rushing yards (fourth in the NFL). He has scored six rushing touchdowns this season.
• He's also hauled in 64 passes (on 81 targets) for 684 receiving yards with two touchdowns. He's averaging 48.9 receving yards and 4.6 catches per game.
• Drake London's 810 receiving yards this season have come from 94 targets and 60 receptions. He's averaging 90.0 receiving yards and 6.7 catches per game, with six receiving touchdowns.
• Kyle Pitts has four touchdown catches this season, and has 73 catches for 797 yards on 97 targets, while averaging 5.2 catches and 56.9 yards per game.
• Tyler Allgeier has run for 396 yards, averaging 28.3 yards per game and scoring eight touchdowns.

Defense

• On the defensive side, Kaden Elliss has 3.5 sacks to go with 10.0 TFL, 94 tackles, and one interception in 2025.
• DeAundre Alford has 50 tackles, 4.0 TFL, two sacks, and two interceptions this season.
• Jessie Bates III has recorded 85 tackles, 1.0 TFL, and two interceptions this year.
• This season, Xavier Watts has 75 tackles and three interceptions. He's third on the Falcons in tackles.

Arizona Betting Info

• Arizona has registered a 6-8-0 record against the spread this season.
• This year, the Cardinals have an against-the-spread record of 4-4 in their eight games as an underdog of 3 points or more.
• This year, Arizona games have hit the over nine times.
• The Cardinals have been underdogs in 11 games this season and won one (9.1%) of those contests.
• The moneyline for this contest implies a 43.5% chance of a victory for the Cardinals.

Cardinals Stats

Arizona's Key Players

Offense

• Jacoby Brissett has thrown for 2,708 yards this year, with 18 touchdowns and six interceptions. He is completing 66.3% of his passes while averaging 246.2 yards per game and 7.0 per attempt.
• Brissett has also rushed for one touchdown and 144 yards (sixth on the Cardinals).
• Trey McBride has 105 catches (second in the NFL) for 1,071 yards (sixth in the NFL) and 10 receiving touchdowns (third in the NFL). He has been targeted 140 times and averages 7.5 receptions per game through 14 games played.
• In 14 games played this season, Michael Wilson has 66 catches (4.7 receptions per game on 7.5 targets per game) for 766 yards and four receiving touchdowns.
• Marvin Harrison Jr. has 594 receiving yards and four touchdowns from 40 receptions after receiving 69 targets.

Defense

• Josh Sweat has 26 tackles, 12.0 TFL, 11 sacks, and two passes defended in 2025.
• Budda Baker's stats include one interception as well as 101 tackles, 2.0 TFL, 0.5 sacks, and four passes defended.
• Akeem Davis-Gaither has recorded 2.0 TFL, 79 tackles, and one interception in the 2025 campaign.
• Jalen Thompson's season stats include 81 tackles, 2.0 TFL, and one sack through 13 games. He is second on the Cardinals in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Cardinals

Atlanta Falcons