Falcons vs. Cardinals 2025 Prediction, Odds, Picks - Dec 21

The Atlanta Falcons (5-9) are slight favorites (-2.5) over the Arizona Cardinals (3-11). The Cardinals have dropped six games straight. An over/under of 48.5 points has been set for the matchup.

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Falcons vs. Cardinals Odds & Betting Lines

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Falcons vs. Cardinals Prediction & Pick

• Pick ATS: Cardinals (+2.5)
  
• Pick OU: Under (48.5)
  
• Prediction: Cardinals 24 - Falcons 23

How to Watch Atlanta vs. Arizona

• Game date: Sunday, December 21, 2025
• Time: 4:05 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Falcons vs. Cardinals Recent Matchups

• Atlanta and Arizona have been evenly matched over their last four games, sharing the same 2-2 record.
• Over their last four head-to-head contests, Atlanta has racked up 116 points, while Arizona has accumulated 92.

Atlanta Betting Info

• Against the spread, Atlanta is 7-7-0 this year.
• The Falcons have been favored by 2.5 points or more five times this season, and covered the spread in one of those contests.
• Atlanta contests this year have eclipsed the over/under 50% of the time (seven times in 14 games with a set point total).
• When playing as the moneyline favorite, the Falcons have won 20% of the time (1-4).
• The Falcons have an implied win probability, based on the moneyline, of 60.8%.

Falcons Stats

Atlanta's Key Players

Offense

• On the ground, Bijan Robinson averages 5.0 yards per attempt (eighth in the NFL) and 83.9 yards per game for 1,174 total rushing yards (fourth in the NFL). He has scored six rushing touchdowns this season.
• Robinson has been targeted 81 times in the passing game and has 64 catches (4.6 per game) for 684 yards (48.9 per game) and two TDs.
• Drake London's 810 receiving yards this season have come from 94 targets and 60 receptions. He's averaging 90.0 receiving yards and 6.7 catches per game, with six receiving touchdowns.
• In the passing game, Kyle Pitts, has contributed with 797 receiving yards and four touchdowns after grabbing 73 balls on 97 targets. Per game, he's averaging 56.9 yards and 5.2 receptions through 14 games.
• Tyler Allgeier has rushed for 396 yards, averaging 28.3 yards per game and scoring eight touchdowns.

Defense

• Over on the defensive side, Kaden Elliss has 94 tackles, 10.0 TFL, 3.5 sacks, and one interception in 2025.
• DeAundre Alford has 50 tackles, 4.0 TFL, two sacks, and two interceptions this season.
• Jessie Bates III has totaled 85 tackles, 1.0 TFL, and two interceptions this year. He's second on the Falcons in tackles.
• This season, Xavier Watts has 75 tackles and three interceptions. He's third on the Falcons in tackles.

Arizona Betting Info

• Arizona is 6-8-0 against the spread this year.
• So far this year, the Cardinals have been installed as underdogs by a 2.5-point margin or more nine times and are 4-5 ATS in those contests.
• Arizona's games have finished with a final combined score above the over/under nine times this year.
• The Cardinals have won one, or 9.1%, of the 11 games they've played as underdogs this season.
• The moneyline for this contest implies a 43.5% chance of a victory for the Cardinals.

Cardinals Stats

Arizona's Key Players

Offense

• Jacoby Brissett is averaging 7.0 passing yards per attempt (17th in the NFL) and 246.2 yards per game this year, completing 66.3% of his passes on the way to 2,708 total yards, 18 touchdowns and six interceptions through 11 games.
• Brissett has also rushed for one touchdown and 144 yards (sixth on the Cardinals).
• Trey McBride has 1,071 receiving yards (sixth in the NFL) and 10 touchdowns (third in the NFL) on 105 receptions (second in the NFL), while being targeted 140 times.
• Through 14 games played this season, Michael Wilson has 66 catches (4.7 receptions per game on 7.5 targets per game) for 766 yards and four receiving touchdowns.
• Marvin Harrison Jr. has 594 receiving yards and four touchdowns from 40 receptions after getting 69 targets.

Defense

• Josh Sweat's 2025 showing includes 26 tackles, 12.0 TFL, and 11 sacks in 13 games.
• Budda Baker's stat sheet includes one interception as well as 101 tackles, 2.0 TFL, 0.5 sacks, and four passes defended.
• Akeem Davis-Gaither has 2.0 TFL, 79 tackles, and one interception.
• Jalen Thompson's stat sheet includes 81 tackles, 2.0 TFL, one sack, and six passes defended in 13 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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