Chiefs vs. Giants 2025 Prediction, Odds, Picks - Sep 21

The Kansas City Chiefs (0-2) are favored by six points against the New York Giants (0-2) on September 21, 2025, starting at 8:20 p.m. ET, airing on NBC. The expected point total for the matchup is 44.5.

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Chiefs vs. Giants Odds & Betting Lines

Chiefs vs. Giants Prediction & Pick

• Pick ATS: Chiefs (-6)
  
• Pick OU: Under (44.5)
  
• Prediction: Chiefs 28 - Giants 12

How to Watch Kansas City vs. New York

• Game date: Sunday, September 21, 2025
• Time: 8:20 p.m. ET
• Venue: MetLife Stadium
• Location: East Rutherford, New Jersey
• TV: NBC
• Live Boxscore: FOX Sports

Chiefs vs. Giants Recent Matchups

• The last two times New York and Kansas City have squared off, the two teams share a split 1-1 record.
• Kansas City and New York have matched up evenly on offense over their past two matchups, with each team putting up 29 points in those games.

Kansas City Betting Info

• Thus far this season, Kansas City is winless versus the spread.
• Kansas City's games this year have gone over the point total one time in two opportunities (50%).
• The Chiefs have been moneyline favorites one other time this season, a game they lost.
• The Chiefs have a 75.3% chance to win this matchup, based on the implied probability of the moneyline.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes has passed for 445 yards, two touchdowns and one interception this year. He averages 222.5 yards per game and 6.5 per attempt, while completing 58.8% of his attempts.
• He has tacked on 123 rushing yards (61.5 per game) and two touchdowns on the ground.
• Travis Kelce has caught six passes on 10 targets for 108 total yards and one touchdown. He is averaging three catches and 54 yards per game through two games.
• In the passing game, Tyquan Thornton, has racked up 100 receiving yards and one touchdown after catching four balls on nine targets. Per game, he's averaging 50 yards and two receptions over two games.
• Marquise Brown has racked up 129 receiving yards without a touchdown with 15 catches (sixth in the NFL) on 21 targets. He is averaging 7.5 receptions and 64.5 yards per game.

Defense

• On defense for the Chiefs, Drue Tranquill has put up 11 tackles, two TFL, and two sacks in 2025.
• Chamarri Conner has 18 tackles this season. His tackle total leads the Chiefs.
• This season, Jaylen Watson has put up 15 tackles.
• Nick Bolton has 14 tackles.

New York Betting Info

• New York has put together a record of 1-1-0 against the spread this season.
• This year, the Giants are winless ATS when entering a game as an underdog of 6 points or more.
• New York games have gone over the total once this year.
• The Giants have lost both games they've played as underdogs this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Giants have a 29.0% chance to win.

Giants Stats

New York's Key Players

Offense

• Russell Wilson is averaging 7.9 passing yards per attempt (seventh in the NFL) and 309 yards per game this year, completing 60.3% of his passes on the way to 618 total yards (second in the NFL), three touchdowns and one interception through two games.
• He's added 67 yards on the ground (first on the Giants), while scoring zero rushing touchdowns. He's averaging 33.5 yards per game and 6.1 per attempt.
• Malik Nabers has 238 receiving yards (first in the NFL) and two touchdowns (fifth in the NFL) on 14 receptions (ninth in the NFL), while being targeted 25 times.
• This season, Wan'Dale Robinson has caught 14 passes (ninth in the NFL) for 197 receiving yards (seventh in the NFL) with one touchdown in the passing game. He has been targeted 18 total times and is averaging seven receptions per game through two games played.
• Cam Skattebo has 42 rushing yards (second on the Giants) and one rushing touchdown, while averaging 21 yards per game and 3.2 per carry (38th in the NFL).
• Skattebo has also caught four passes for 26 yards (sixth on the Giants). He's been targeted five times and averages 13 yards per game.

Defense

• So far in 2025, Brian Burns has put up three sacks to go with four TFL and nine tackles over two games. He ranks fourth in the NFL in sacks.
• Paulson Adebo has 20 tackles.
• Bobby Okereke has 26 tackles.
• Andru Phillips has intercepted one pass in addition to 15 tackles, one TFL, and two passes defended. He's third in the NFL in interceptions.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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