Chargers vs. Broncos 2025 Prediction, Odds, Picks - Sep 21

The Los Angeles Chargers (2-0) are small favorites (-2.5) against the Denver Broncos (1-1) in a matchup of two division rivals. An over/under of 45.5 points has been established for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

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Chargers vs. Broncos Odds & Betting Lines

Chargers vs. Broncos Prediction & Pick

• Pick ATS: Broncos (+2.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Chargers 22 - Broncos 21

How to Watch Los Angeles vs. Denver

• Game date: Sunday, September 21, 2025
• Time: 4:05 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: CBS
• Live Boxscore: FOX Sports

Chargers vs. Broncos Recent Matchups

• Over their last five meetings, Denver has collected three wins against Los Angeles.
• Los Angeles has been outscored by 13 points in its last five tilts against Denver.

Los Angeles Betting Info

• Los Angeles is undefeated against the spread this season.
• The Chargers have been favored by 2.5 points or more once this season, and covered the spread.
• Los Angeles' games this year have hit the over one time in two opportunities (50%).
• The Chargers have been moneyline favorites a single other time this season, a game they won.
• The Chargers have an implied win probability, based on the moneyline, of 60.8%.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has passed for 560 yards (fifth in the NFL), five touchdowns (third in the NFL) and zero interceptions this year. He averages 280.0 yards per game and 9.2 per attempt, while completing 72.1% of his attempts.
• He has tacked on 63 rushing yards (31.5 per game) without a touchdown on the ground.
• Quentin Johnston's 150 receiving yards this season have come from 14 targets and eight receptions. He's averaging 75.0 receiving yards and 4.0 catches per game, with three receiving touchdowns (first in the NFL).
• Through two games played, Keenan Allen is averaging 64.5 yards and 6.0 receptions per game on the way to 129 receiving yards and 12 catches. He's been targeted 17 times, and has two receiving touchdowns (fifth in the NFL).
• Ladd McConkey has racked up 122 receiving yards without a touchdown with 11 catches on 14 targets. He's averaging 5.5 receptions and 61.0 yards per game.

Defense

• Over on the defensive side, Daiyan Henley has one interception (third in the NFL) to go with 18 tackles, 3.0 TFL, two sacks, and two passes defended in 2025.
• Derwin James has 14 tackles and 1.0 TFL this season. He's second on the Chargers in tackles.
• Tarheeb Still has collected 12 tackles and 1.0 TFL this year.
• Tuli Tuipulotu has 1.0 TFL and six tackles this year.

Denver Betting Info

• Denver is winless against the spread this season (0-2-0).
• Denver games have gone over the total once this year.
• The Broncos have not played a game this season while listed as the underdog.
• The implied probability of a win by the Broncos based on the moneyline is 43.5%.

Broncos Stats

Denver's Key Players

Offense

• This year through two games, J.K. Dobbins has racked up 139 rushing yards (leading the Broncos) and scored two rushing touchdowns. He averages 69.5 yards per game and 4.6 per carry (16th in the NFL).
• Through two games, Bo Nix has 382 passing yards, with four touchdowns (eighth in the NFL) against three interceptions and completing 67.1% of his passes.
• Nix also has 38 rushing yards (third on the Broncos).
• Through two games played this season, Troy Franklin has 12 catches (6.0 receptions per game on 7.5 targets per game) for 133 yards and one receiving touchdown.
• Courtland Sutton has been targeted 13 times, resulting in seven catches for 67 yards .

Defense

• In 2025, Talanoa Hufanga has put up 21 tackles over two games.
• Justin Strnad has 2.0 sacks (first on the Broncos and ninth in the NFL) to go with 2.0 TFL and 10 tackles.
• Over the 2025 campaign, Zach Allen has six tackles, 1.0 TFL, and one sack in two games.
• Nik Bonitto has six tackles, 2.0 TFL, and one sack.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Chargers

Denver Broncos