Buccaneers vs. Panthers 2025 Prediction, Odds, Picks - Dec 21

The Tampa Bay Buccaneers (7-7) are slight favorites (-2.5) against the Carolina Panthers (7-7) in a battle of two division rivals. The total for this one is set at 45.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Buccaneers vs. Panthers Odds & Betting Lines

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Buccaneers vs. Panthers Prediction & Pick

• Pick ATS: Panthers (+2.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Buccaneers 23 - Panthers 22

How to Watch Tampa Bay vs. Carolina

• Game date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• Venue: Bank of America Stadium
• Location: Charlotte, North Carolina
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Buccaneers vs. Panthers Recent Matchups

• Over their last five meetings, Tampa Bay has collected five wins versus Carolina.
• Over their last five head-to-head contests, Tampa Bay has put up 134 points, while Carolina has compiled 79.

Tampa Bay Betting Info

• Against the spread, Tampa Bay is 5-9-0 this season.
• The Buccaneers have covered the spread twice when favored by 2.5 points or more this season (in seven opportunities).
• Tampa Bay games in 2025 have eclipsed the over/under eight times in 14 opportunities (57.1%).
• The Buccaneers have won 62.5% of the time they have played as the moneyline favorite (5-3).
• Based on this contest's moneyline, the Buccaneers' implied win probability is 59.7%.

Buccaneers Stats

Tampa Bay's Key Players

Offense

• Baker Mayfield has thrown for 2,999 yards, 22 touchdowns and seven interceptions this year. He is averaging 214.2 yards per game and 6.6 per attempt, while completing 61.2% of his attempts.
• He has also rushed for 286 yards (fourth on the Buccaneers) and added one touchdown on the ground, while averaging 20.4 rushing yards per game.
• Emeka Egbuka's 870 receiving yards this season have come from 117 targets and 58 receptions. He's averaging 62.1 receiving yards and 4.1 catches per game, with six receiving touchdowns.
• Through 14 games, Rachaad White has picked up 494 yards on the ground, averaging 35.3 yards per game and scoring four touchdowns.
• White has recorded 34 receptions, 178 yards and zero TDs in the passing game.
• Bucky Irving has rushed for 413 yards with one touchdown (59 yards per game through seven games).
• Irving's 27 receiving targets have resulted in 24 receptions (3.4 per game) for 250 yards (35.7 per game) and three TDs.

Defense

• Over on the defensive side, Tykee Smith has 90 tackles, six TFL, two sacks, and one interception in 2025.
• Lavonte David has 96 tackles, seven TFL, 2.5 sacks, and one interception this season.
• Antoine Winfield Jr. has totaled 81 tackles, four TFL, one sack, and two interceptions this year.
• This season, SirVocea Dennis has 83 tackles, seven TFL, two sacks, and one interception.

Carolina Betting Info

• Carolina has covered the spread in a matchup eight times this season (8-6-0).
• This season, the Panthers have an against-the-spread record of 6-4 in their 10 games as an underdog of 2.5 points or more.
• This year, Carolina games have hit the over seven times.
• The Panthers have been underdogs in 12 games this season and won seven (58.3%) of those contests.
• The sportsbooks' moneyline implies a 44.6% chance of a victory for the Panthers.

Panthers Stats

Carolina's Key Players

Offense

• Bryce Young has passed for 2,500 yards this year, with 19 touchdowns and nine interceptions. He is completing 63.3% of his passes while averaging 192.3 yards per game and 6.5 per attempt.
• Young has also rushed for one touchdown and 170 yards (third on the Panthers).
• Rico Dowdle has 978 rushing yards (leading the Panthers and ninth in the NFL) and six rushing touchdowns, while averaging 69.9 yards per game and 4.7 per carry (14th in the NFL).
• Dowdle has also collected 259 receiving yards (18.5 per game) on 30 catches (2.1 per game). He's been targeted 37 times and has caught one touchdown pass.
• So far this season, Tetairoa McMillan has caught 59 passes for 851 receiving yards with six touchdowns through the air. He has been targeted 102 total times and is averaging 4.2 receptions per game in 14 games played.
• Chuba Hubbard has scored one touchdown on the ground, while running for 462 total yards (3.9 per attempt and 38.5 per game).
• Hubbard also has 203 receiving yards (16.9 per game) on 24 catches (two per game). He has been targeted 33 times with three touchdown receptions.

Defense

• Tre'von Moehrig has intercepted one pass to go with 86 tackles, 10 TFL, one sack, and two passes defended in 2025.
• Christian Rozeboom has one sack to go with five TFL and 97 tackles.
• Nick Scott has 83 tackles and one interception in the 2025 season.
• Mike Jackson Sr.'s stat sheet includes three interceptions as well as 48 tackles, three TFL, and 14 passes defended in 14 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Carolina Panthers

Tampa Bay Buccaneers