Buccaneers vs. Panthers 2025 Prediction, Odds, Picks - Dec 21

The Tampa Bay Buccaneers (7-7) are the favorites -- expected to win by at least a field goal, but less than a touchdown (currently -3) -- versus the Carolina Panthers (7-7) in a battle of two division rivals. The over/under for this one is set at 44.5 points.

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Buccaneers vs. Panthers Odds & Betting Lines

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Buccaneers vs. Panthers Prediction & Pick

• Pick ATS: Panthers (+3)
  
• Pick OU: Over (44.5)
  
• Prediction: Buccaneers 23 - Panthers 22

How to Watch Tampa Bay vs. Carolina

• Game date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• Venue: Bank of America Stadium
• Location: Charlotte, North Carolina
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Buccaneers vs. Panthers Recent Matchups

• Tampa Bay owns a 5-0 record against Carolina in their last five matchups.
• Carolina has been outscored by 55 points in its last five tilts versus Tampa Bay.

Tampa Bay Betting Info

• Tampa Bay is 5-9-0 against the spread this season.
• The Buccaneers have been favored by 3 points or more seven times this season, and covered the spread in two of those matchups.
• Tampa Bay games this year have hit the over on eight of 14 set point totals (57.1%).
• The Buccaneers have won 62.5% of the time they have played as moneyline favorites (5-3).
• Based on this matchup's moneyline, the Buccaneers' implied win probability is 60.8%.

Buccaneers Stats

Tampa Bay's Key Players

Offense

• Baker Mayfield has thrown for 2,999 yards, 22 touchdowns and seven interceptions this year. He averages 214.2 yards per game and 6.6 per attempt, while completing 61.2% of his attempts.
• He has also rushed for 286 yards (fourth on the Buccaneers) and added one touchdown on the ground, while averaging 20.4 rushing yards per game.
• Emeka Egbuka has 58 receptions for 870 yards and six TDs. In 14 games, he is averaging 4.1 catches and 62.1 yards per game.
• In 14 games, Rachaad White has picked up 494 yards on the ground, averaging 35.3 yards per game and scoring four touchdowns.
• White has totaled 34 receptions on 39 targets for 178 yards, but he has yet to score a receiving touchdown.
• Bucky Irving has rushed for 413 yards, averaging 59 yards per game and scoring one touchdown.
• He has added 24 catches (on 27 targets) for 250 receiving yards with three touchdowns. He's averaging 35.7 receiving yards and 3.4 receptions per game.

Defense

• On defense for the Buccaneers, Tykee Smith has powered the unit with 90 tackles, six TFL, two sacks, and one interception in 2025.
• Lavonte David has 96 tackles, seven TFL, 2.5 sacks, and one interception this season. His tackle total leads the Buccaneers.
• Antoine Winfield Jr. has put up 81 tackles, four TFL, one sack, and two interceptions this year. He's fourth on the Buccaneers in tackles.
• This season, SirVocea Dennis has 83 tackles, seven TFL, two sacks, and one interception. He's third on the Buccaneers in tackles.

Carolina Betting Info

• Carolina has registered an 8-6-0 record against the spread this year.
• The Panthers have an against the spread record of 6-4 in their 10 games as an underdog of 3 points or more this year.
• This year, seven Carolina games have gone over the point total.
• The Panthers have entered the game as underdogs 12 times this season and won seven, or 58.3%, of those games.
• The oddsmakers' moneyline implies a 43.5% chance of a victory for the Panthers.

Panthers Stats

Carolina's Key Players

Offense

• Through 13 games played this year, Bryce Young has racked up 2,500 passing yards, while throwing 19 touchdowns against nine interceptions and completing 63.3% of his attempts.
• Young has also rushed for one touchdown and 170 yards (third on the Panthers).
• Rico Dowdle averages 69.9 rushing yards per game through 14 games (978 total yards), while scoring six rushing touchdowns.
• Dowdle also has 30 catches for 259 yards (fourth on the Panthers), with one receiving touchdown. He has been targeted 37 times and averages 18.5 yards per game.
• Tetairoa McMillan has put up 851 receiving yards and six touchdowns on 59 receptions, while being targeted 102 times this season.
• Chuba Hubbard has 462 rushing yards (second on the Panthers) and one rushing touchdown, while averaging 38.5 yards per game and 3.9 per carry (37th in the NFL).
• Hubbard also has 203 receiving yards (16.9 per game) on 24 catches (two per game). He has been targeted 33 times with three touchdown receptions.

Defense

• Tre'von Moehrig has amassed one sack to go with 10 TFL, 86 tackles, and one interception over 13 games in 2025.
• Christian Rozeboom has 97 tackles, five TFL, one sack, and one pass defended.
• Nick Scott has 83 tackles and one interception in the 2025 season. He is third on the Panthers in tackles.
• Mike Jackson Sr. has intercepted three passes to go with 48 tackles, three TFL, and 14 passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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