Broncos vs. Chargers 2025 Prediction, Odds, Picks - Jan 4

The Denver Broncos (13-3) and Los Angeles Chargers (11-5) will play each other in a battle of two division rivals. The Broncos are big favorites (-12.5). The expected point total for the matchup is set at 37.5.

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Broncos vs. Chargers Odds & Betting Lines

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Broncos vs. Chargers Prediction & Pick

• Pick ATS: Chargers (+12.5)
  
• Pick OU: Over (37.5)
  
• Prediction: Broncos 24 - Chargers 19

How to Watch Denver vs. Los Angeles

• Game date: Sunday, January 4, 2026
• Time: 4:25 p.m. ET
• Venue: Empower Field at Mile High
• Location: Denver, Colorado
• TV:
• Live Boxscore: FOX Sports

Broncos vs. Chargers Recent Matchups

• Over their last five meetings, Los Angeles has totaled three wins versus Denver.
• In their last five head-to-head matchups, Denver has tallied 103 points versus Los Angeles, while surrendering only 96 points.

Denver Betting Info

• Against the spread, Denver is 6-10-0 this season.
• The Broncos have not covered the spread when favored by 12.5 points or more this season (in one opportunity).
• Denver games this year have hit the over on seven of 16 set point totals (43.8%).
• When playing as the moneyline favorite, the Broncos are 9-2 (winning 81.8% of the time).
• The implied probability in this matchup, considering the moneyline, gives the Broncos a 92.3% chance to win.

Broncos Stats

Denver's Key Players

Offense

• Bo Nix ranks sixth in the NFL with 3,790 passing yards through 16 games this year, averaging 236.9 per game with a 63.5% completion percentage and 25 touchdowns (seventh in the NFL) against 11 interceptions.
• He has tacked on 307 rushing yards (19.2 per game) and five touchdowns on the ground.
• RJ Harvey has put up 512 rushing yards with seven touchdowns (32.0 yards per game across 16 games). His 3.9 yards per attempt rank 37th in the league.
• Harvey's 54 targets as part of the passing attack have turned into 46 catches (2.9 per game) for 351 yards (21.9 per game) and five touchdowns.
• In 16 games played, Courtland Sutton is averaging 63.3 yards and 4.6 receptions per game to total 1,012 receiving yards and 73 catches. He's been targeted 122 times, and has seven receiving touchdowns.
• Troy Franklin averages 4.1 receptions and 44.3 yards per game, and has 709 total receiving yards and 65 catches. He's gotten 103 total targets, and has caught six touchdown passes.

Defense

• On defense, Nik Bonitto has 44 tackles, 13.0 TFL, and 12.5 sacks in 2025.
• Talanoa Hufanga has 2.0 sacks to go with 6.0 TFL and 103 tackles.
• This season, Alex Singleton has recorded 1.0 sack to go with his 3.0 TFL and 128 tackles.
• So far this season, Zach Allen has 36 tackles, 3.0 TFL, and 6.5 sacks.

Los Angeles Betting Info

• Los Angeles is 9-7-0 against the spread this year.
• This year, Los Angeles games have hit the over six times.
• This season, the Chargers have been listed as the underdog in four games but won them all.
• Sportsbooks have implied with the moneyline set for this matchup that the Chargers have a 11.8% chance to win.

Chargers Stats

Los Angeles' Key Players

Offense

• In 16 games played this year, Justin Herbert has amassed 3,727 passing yards (ninth-best in the NFL), while throwing 26 touchdowns (fifth in the NFL) against 13 interceptions and completing 66.4% of his attempts.
• Herbert has also rushed for two touchdowns and 498 yards (third on the Chargers).
• Quentin Johnston has 51 catches for 735 yards and eight receiving touchdowns. He has been targeted 85 times and averages 3.9 receptions per game through 13 games played.
• This season, Ladd McConkey has caught 66 passes for 789 receiving yards with six touchdowns in the passing game. He has been targeted 106 total times and is averaging 4.1 receptions per game in 16 games played.
• Omarion Hampton has scored four touchdowns on the ground, while running for 545 total yards (4.4 per attempt and 60.6 per game).
• Hampton also has 192 receiving yards (21.3 per game) on 32 catches (3.6 per game). He has been targeted 35 times with one touchdown reception.

Defense

• Tuli Tuipulotu has 45 tackles, 20.0 TFL, 13 sacks, and three passes defended in 2025.
• Daiyan Henley has 3.5 sacks (fifth on the Chargers) to go with 5.0 TFL, 101 tackles, and two interceptions.
• Derwin James has 94 tackles, 6.0 TFL, two sacks, and three interceptions in the 2025 season. He is second on the Chargers in tackles.
• Odafe Oweh has 34 tackles, 9.0 TFL, and seven sacks.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Denver Broncos

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