Broncos vs. Bills 2025 Divisional Round Prediction, Odds, Picks - Jan 17

Updated Jan. 17, 2026 2:44 p.m. ET

Data Skrive

The Denver Broncos and Buffalo Bills will feature in the AFC Divisional round of the 2025 NFL Playoffs. The Broncos are slim favorites (-1.5). The total for this one is set at 46.5 points.

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Broncos vs. Bills Odds & Betting Lines

Broncos vs Bills Betting Information updated as of January 16, 2026, 7:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Broncos	-1.5	-108	-112	46.5	-108	-123

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Broncos vs. Bills Prediction & Pick

Pick ATS: Bills (+1.5)
Pick OU: Under (46.5)
Prediction: Broncos 24 - Bills 23

How to Watch Denver vs. Buffalo

Game date: Saturday, January 17, 2026
Time: 4:30 p.m. ET
Venue: Empower Field at Mile High
Location: Denver, Colorado
TV: CBS
Live Boxscore: FOX Sports

Broncos vs. Bills Recent Matchups

Over their last four meetings, Buffalo has three wins versus Denver.
Over their last four head-to-head matchups, Buffalo has put up 99 points, while Denver has accumulated 50.

Denver Betting Info

In 17 Denver games this year, it has seven wins against the spread.
The Broncos have covered the spread three times this season (3-9 ATS) when playing as at least 1.5-point favorites.
Denver contests this year have hit the over 41.2% of the time (seven times in 17 games with a set point total).
When playing as the moneyline favorite, the Broncos have won 83.3% of the time (10-2).
The Broncos have an implied win probability, based on the moneyline, of 54.5%.

Broncos Stats

Stat	Average (Total)	Rank
Pass yards	223.9 (3,807)	11
Rush yards	118.7 (2,018)	16
Points scored	23.6 (401)	14
Pass yards against	187.2 (3,182)	7
Rush yards against	91.1 (1,548)	2
Points allowed	18.3 (311)	3

Denver's Key Players

Offense

Bo Nix has 3,931 passing yards (eighth in the NFL), 25 touchdowns (ninth in the NFL) and 11 interceptions this year. He has completed 63.4% of his passes, averaging 231.2 yards per game and 6.4 per attempt.
He has also rushed for 356 yards (third on the Broncos) and added five touchdowns on the ground, while averaging 20.9 rushing yards per game.
RJ Harvey has collected 540 rushing yards with seven touchdowns (31.8 yards per game through 17 games). His 3.7 yards per attempt rank 41st in the NFL.
Harvey has 47 receptions on 58 targets for 356 yards. He has five receiving TDs.
In the passing game, Courtland Sutton, has contributed with 1,017 receiving yards and seven touchdowns after hauling in 74 balls on 124 targets. Per game, he's averaging 59.8 yards and 4.4 receptions in 17 games.
Troy Franklin has racked up 709 receiving yards and six touchdowns with 65 catches on 104 targets. He's averaging 3.8 receptions and 41.7 yards per game.

Defense

On the defensive side for the Broncos, Nik Bonitto has powered the unit with 46 tackles, 14.0 TFL, and 14 sacks in 2025.
Talanoa Hufanga has 106 tackles, 6.0 TFL, and two sacks this season. He's second on the Broncos in tackles.
Alex Singleton has recorded 135 tackles, 3.0 TFL, one sack, and four passes defended.
Zach Allen has 7.0 sacks (fourth on the Broncos) as well as 4.0 TFL and 38 tackles on the season.

Buffalo Betting Info

Buffalo covered the spread eight times in 17 games in the regular season. In the playoffs, it has an ATS record of 1-0-0.
The Bills are yet to lose ATS (2-0) as 1.5-point underdogs or more in the regular season and playoffs.
During the regular season, nine of Buffalo's 17 games went over the point total. Meanwhile, in the postseason, it has eclipsed the total in zero of one games.
The Bills won both games they played as underdogs in the regular season, and are 1-0 in the playoffs.
The implied probability of a win by the Bills based on the moneyline is 50.0%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	216.6 (3,683)	15
Rush yards	159.6 (2,714)	1
Points scored	28.3 (481)	4
Pass yards against	156.9 (2,668)	1
Rush yards against	136.2 (2,315)	28
Points allowed	21.5 (365)	12

Buffalo's Key Players

Offense

Josh Allen has passed for 3,668 yards this year, with 25 touchdowns (ninth in the NFL) and 10 interceptions. He is completing 69.3% of his passes while averaging 229.3 yards per game and 8.0 per attempt.
On the ground, Josh Allen has added 14 rushing touchdowns and 579 rushing yards (second on the Bills).
James Cook has scored 12 rushing touchdowns, while totaling 1,621 rushing yards (5.2 per attempt and 95.4 per game).
Cook has also picked up 291 receiving yards (17.1 per game) on 33 catches (1.9 per game). He's been targeted 40 times and has caught two touchdown passes.
Khalil Shakir has registered 719 receiving yards and four touchdowns on 72 receptions, while being targeted 95 times this season.
Dalton Kincaid has 571 receiving yards and five touchdowns from 39 receptions after receiving 49 targets.

Defense

Cole Bishop has intercepted three passes and also has 85 tackles, 4.0 TFL, two sacks, and seven passes defended in 2025.
Greg Rousseau has 7.0 sacks (first on the Bills) to go with 6.0 TFL and 46 tackles.
Over the 2025 season, Joey Bosa has 29 tackles, 9.0 TFL, and five sacks in 15 games.
Matt Milano has registered 3.5 sacks (third on the Bills) to go with 7.0 TFL and 67 tackles through 12 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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