Bills vs. Saints 2025 Prediction, Odds, Picks - Sep 28

The Buffalo Bills (3-0) are big favorites, expected to win by two touchdowns or more (currently -14.5) over the New Orleans Saints (0-3). The Saints have dropped three games straight. The matchup has an over/under of 48.5 points.

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Bills vs. Saints Odds & Betting Lines

Bills vs. Saints Prediction & Pick

• Pick ATS: Bills (-14.5)
  
• Pick OU: Under (48.5)
  
• Prediction: Bills 34 - Saints 14

How to Watch Buffalo vs. New Orleans

• Game date: Sunday, September 28, 2025
• Time: 1 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: CBS
• Live Boxscore: FOX Sports

Bills vs. Saints Recent Matchups

• In their past two matchups, New Orleans has a split 1-1 record against Buffalo.
• In their last two head-to-head matchups, New Orleans has compiled 53 points against Buffalo, while allowing only 41 points.

Buffalo Betting Info

• So far this season Buffalo has two victories against the spread.
• Buffalo games this year have gone over the point total two times in three opportunities (66.7%).
• The Bills have been moneyline favorites in two other games this season, and they won both.
• The Bills have an implied win probability, based on the moneyline, of 93.1%.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has passed for 755 yards (ninth in the NFL), five touchdowns (eighth in the NFL) and zero interceptions this year. He is averaging 251.7 yards per game and 7.6 per attempt, while completing 69.7% of his attempts.
• He has added 114 rushing yards (38 per game) and two touchdowns on the ground.
• James Cook's rushing statline this season includes 284 yards (second in the NFL) and four TDs. He's averaging 94.7 yards per game and 5.4 per attempt (ninth in the NFL).
• He has hauled in nine passes (on nine targets) for 71 receiving yards with zero touchdowns. He's averaging 23.7 receiving yards and three catches per game.
• Through three games played, Dalton Kincaid is averaging 50.3 yards and 4.3 receptions per game to total 151 receiving yards and 13 catches. He's been targeted 16 times, and has two receiving touchdowns (seventh in the NFL).
• Keon Coleman averages 4.7 receptions and 52.7 yards per game, and has 158 total receiving yards and 14 catches. He's gotten 18 total targets, and has caught one touchdown pass.

Defense

• Over on the defensive side, Terrel Bernard has one interception (eighth in the NFL) to go with 14 tackles, two TFL, and one pass defended in 2025.
• Joey Bosa has five tackles, one TFL, and one sack.
• Cole Bishop has totaled 14 tackles, one TFL, and one sack this year. He's second on the Bills in tackles.
• Ed Oliver has one sack (first on the Bills) to go with three TFL and six tackles on the season.

New Orleans Betting Info

• New Orleans has not covered the spread in any game this season (0-3-0).
• This year, New Orleans games have hit the over twice.
• The Saints have been the underdog in three games this season, and they have failed to win any of those contests.
• Oddsmakers have implied with the moneyline set for this matchup that the Saints have a 11.1% chance to win.

Saints Stats

New Orleans' Key Players

Offense

• Through three games played this year, Spencer Rattler has amassed 639 passing yards, while throwing four touchdowns against one interception and completing 67.2% of his passes.
• He's added 53 yards on the ground (third on the Saints), while scoring zero rushing touchdowns. He's averaging 17.7 yards per game and 5.3 per attempt.
• Alvin Kamara has scored one rushing touchdown, while totaling 186 rushing yards (3.7 per attempt and 62 per game).
• Kamara has added nine receptions (3 per game) for 47 yards (15.7 per game), without a receiving touchdown. He's been targeted 10 times in the passing game.
• Juwan Johnson has put up 176 receiving yards and one touchdown on 19 receptions (10th in the NFL), while being targeted 28 times this season.
• Rashid Shaheed has 127 receiving yards and one touchdown from 14 receptions after receiving 20 targets.

Defense

• Pete Werner has 27 tackles, one TFL, one sack, and two passes defended in 2025.
• Carl Granderson has 15 tackles, four TFL, 3.5 sacks, and two passes defended.
• Demario Davis has 31 tackles and three TFL in the 2025 campaign.
• Alontae Taylor has totaled one sack (third on the Saints) to go with two TFL and 10 tackles through three games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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