Bills vs. Patriots 2025 Prediction, Odds, Picks - Dec 14

The New England Patriots (11-2) will be aiming to continue a 10-game winning streak against the Buffalo Bills (9-4). Despite that, the Bills are slim favorites (-1.5). An over/under of 49.5 points has been set for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

‘I don’t think Buffalo’s that good’, Are the Bills wasting Josh Allen’s prime? | The Herd

The New England Patriots can clinch the AFC East with a win over the Buffalo Bills on Sunday. Colin Cowherd asks if the Bills are wasting Josh Allen’s prime with a poor receiving room and roster management.

Bills vs. Patriots Odds & Betting Lines

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Bills vs. Patriots Prediction & Pick

• Pick ATS: Patriots (+1.5)
  
• Pick OU: Under (49.5)
  
• Prediction: Patriots 26 - Bills 23

How to Watch Buffalo vs. New England

• Game date: Sunday, December 14, 2025
• Time: 1 p.m. ET
• Venue: Gillette Stadium
• Location: Foxborough, Massachusetts
• TV: CBS
• Live Boxscore: FOX Sports

Bills vs. Patriots Recent Matchups

• New England has a 3-2 record against Buffalo in their last five matchups.
• In their last five head-to-head matchups, New England has racked up 117 points against Buffalo, while surrendering only 112 points.

Buffalo Betting Info

• Buffalo has played 13 games, posting six wins against the spread.
• When playing as at least 1.5-point favorites this season, the Bills have an ATS record of 4-7.
• Buffalo has combined with its opponent to hit the over in 46.2% of its contests this year (six times over 13 games with a set point total).
• When playing as the moneyline favorite, the Bills have won 63.6% of the time (7-4).
• The Bills have a 54.5% chance to win this contest, based on the implied probability of the moneyline.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen ranks eighth in the NFL with 3,083 passing yards through 13 games this year, averaging 237.2 per game with a 70.1% completion percentage and 22 touchdowns (fifth in the NFL) against 10 interceptions.
• He has also rushed for 487 yards (second on the Bills) and added 12 touchdowns on the ground, while averaging 37.5 rushing yards per game.
• James Cook's rushing statline this season includes 1,308 yards (second in the NFL) and eight TDs. He is averaging 100.6 yards per game and 5.3 per attempt (sixth in the NFL).
• Cook's 31 targets in the passing game have turned into 29 catches (2.2 per game) for 267 yards (20.5 per game) and one touchdown.
• Khalil Shakir has four touchdown catches this season, and has 57 catches for 585 yards on 78 targets, while averaging 4.4 catches and 45.0 yards per game.
• Dalton Kincaid has 33 catches for 489 yards and five touchdowns. He's been targeted 41 times in the air attack, and averages 3.7 receptions and 54.3 yards through nine games played.

Defense

• Over on defense, Cole Bishop has three interceptions to go with 71 tackles, 3.0 TFL, two sacks, and seven passes defended in 2025.
• Joey Bosa has 26 tackles, 8.0 TFL, and five sacks.
• Terrel Bernard has totaled 56 tackles, 7.0 TFL, and one interception this year. He's second on the Bills in tackles.
• This season, Christian Benford has 39 tackles, 4.0 TFL, two sacks, and two interceptions.

New England Betting Info

• New England has put together a record of 8-5-0 against the spread this season.
• The Patriots are 3-1 ATS when underdogs by 1.5 points or more this season.
• New England games have gone over the total seven times this season.
• The Patriots have won three of the four games they've played as underdogs this season.
• The Patriots have a 50.0% chance to win this game based on the implied probability of the moneyline.

Patriots Stats

New England's Key Players

Offense

• Drake Maye is averaging 8.8 passing yards per attempt (second in the NFL) and 262.5 yards per game this year, completing 71.5% of his passes on the way to 3,412 total yards (second in the NFL), 23 touchdowns (fourth in the NFL) and six interceptions through 13 games.
• On the ground, Maye has added two rushing touchdowns and 319 rushing yards (third on the Patriots).
• TreVeyon Henderson has scored five rushing touchdowns, while totaling 625 rushing yards (4.8 per attempt and 48.1 per game).
• Henderson also has 32 catches for 199 yards (eighth on the Patriots), with one receiving touchdown. He has been targeted 38 times and averages 15.3 yards per game.
• Through 13 games played this season, Hunter Henry has 45 catches (3.5 receptions per game on 5.3 targets per game) for 610 yards and five receiving touchdowns.
• Stefon Diggs has 64 catches for 705 yards and three receiving touchdowns. He averages 4.9 yards per game through 13 games and has been targeted 79 times.

Defense

• Robert Spillane has intercepted two passes to go with 97 tackles, 4.0 TFL, one sack, and five passes defended in 2025.
• Harold Landry has 46 tackles, 9.0 TFL, and 7.5 sacks.
• Marcus Jones has recorded 1.0 sack as well as 6.0 TFL, 50 tackles, and three interceptions in the 2025 campaign.
• Jaylinn Hawkins' season stats include 50 tackles, 3.0 TFL, 1.5 sacks, and two interceptions in 11 games. He is fifth on the Patriots in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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