
49ers vs. Rams Injury Report – Week 10, 2025
The San Francisco 49ers (6-3) have 16 players on the injury report, including Christian McCaffrey, ahead of their matchup against the Los Angeles Rams (6-2) at Levi's Stadium, on Sunday, Nov. 9 at 4:25 p.m. ET.
Learn more about the Los Angeles Rams vs. the San Francisco 49ers on FOX Sports!
How Packers, Rams, Lions and Eagles shape the NFC's dominance 💪🏻 | FOX NFL Sunday
Rams vs. 49ers Game Info
- When: Sunday, November 9, 2025 at 4:25 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV info: FOX
- Spread Favorite: Rams (-5.5)
- Moneyline: Rams (-250), 49ers (+205)
- Total: 49.5 points
- Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Rams Injuries
Jordan Whittington | WR (Questionable)
- Injury: Back
- Practice Status: Limited Participation in Practice
Puka Nacua | WR
- Injury: Chest
- Practice Status: Full Participation in Practice
- 2025 Receiving Stats: 73 Targets | 61 Receptions | 711 Yards | 3 Touchdowns
AJ Jackson | OL
- Injury: Rest
- Practice Status: Did Not Participate In Practice
- 2025 Season Stats: 1 Games Played
Byron Young | OLB
- Injury: Rest
- Practice Status: Did Not Participate In Practice
- 2025 Defensive Stats: 9.0 Sacks | 9.0 Tackles for Loss | 41 Tackles | 0 Interceptions | 0 Passes Defended
Tyler Higbee | TE
- Injury: Rest
- Practice Status: Did Not Participate In Practice
Darious Williams | CB
- Injury: Shoulder
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 14 Tackles | 0 Interceptions | 7 Passes Defended
49ers Injuries
Mykel Williams | DL (Out)
- Injury: Knee
- Practice Status: Did Not Participate In Practice
- 2025 Defensive Stats: 1.0 Sack | 4.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 0 Passes Defended
Ricky Pearsall | WR (Out)
- Injury: Knee
- Practice Status: Did Not Participate In Practice
- 2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 Touchdowns
Tatum Bethune | LB (Questionable)
- Injury: Thigh
- Practice Status: Limited Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 51 Tackles | 0 Interceptions | 1 Pass Defended
Keion White | DL (Questionable)
- Injury: Groin
- Practice Status: Limited Participation in Practice
Kalia Davis | DL (Questionable)
- Injury: Ankle
- Practice Status: Limited Participation in Practice
Alfred Collins | DT (Questionable)
- Injury: Hip
- Practice Status: Did Not Participate In Practice
Ben Bartch | OL (Questionable)
- Injury: Ankle
- Practice Status: Full Participation in Practice
- 2024 Season Stats: 1 Game Played
Dee Winters | LB (Questionable)
- Injury: Knee
- Practice Status: Limited Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 4.0 Tackles for Loss | 59 Tackles | 0 Interceptions | 3 Passes Defended
Brock Purdy | QB (Questionable)
- Injury: Toe
- Practice Status: Limited Participation in Practice
- 2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 Interceptions
Jake Brendel | OL
- Injury: Hamstring
- Practice Status: Full Participation in Practice
- 2025 Season Stats: 3 Games Played
Trent Williams | OT
- Injury: Rest
- Practice Status: Full Participation in Practice
- 2025 Season Stats: 4 Games Played
Christian McCaffrey | RB
- Injury: Rest
- Practice Status: Full Participation in Practice
- 2025 Rushing: 168 Attempts | 596 Yards | 4 Touchdowns
- 2025 Receiving Stats: 80 Targets | 61 Receptions | 626 Yards | 4 Touchdowns
Darrell Luter | CB
- Injury: Achilles
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 11 Tackles | 0 Interceptions | 0 Passes Defended
Mac Jones | QB
- Injury: Knee
- Practice Status: Full Participation in Practice
- 2025 Passing: 250-for-168 | 1,832 Yards | 10 Touchdowns | 5 Interceptions
Jauan Jennings | WR
- Injury: Ankle
- Practice Status: Full Participation in Practice
- 2025 Receiving Stats: 41 Targets | 22 Receptions | 253 Yards | 2 Touchdowns
Bryce Huff | DL
- Injury: Hamstring
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 4.0 Sacks | 6.0 Tackles for Loss | 19 Tackles | 0 Interceptions | 1 Pass Defended
Rams vs. 49ers Head-to-Head History
- Los Angeles has a 3-2 record against San Francisco in their last five matchups.
- Los Angeles and San Francisco have matched up evenly on offense over their last five matchups, with each team producing 106 total points in those games.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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