49ers vs. Rams Injury Report – Week 10, 2025

The San Francisco 49ers (6-3) have 16 players on the injury report, including Christian McCaffrey, ahead of their matchup against the Los Angeles Rams (6-2) at Levi's Stadium, on Sunday, Nov. 9 at 4:25 p.m. ET.

Learn more about the Los Angeles Rams vs. the San Francisco 49ers on FOX Sports!

How Packers, Rams, Lions and Eagles shape the NFC's dominance 💪🏻 | FOX NFL Sunday

The "FOX NFL Sunday" and "FOX NFL Kickoff" crews break down the NFC's dominance all season and the biggest storylines, from the Los Angeles Rams-San Francisco 49ers NFC West battle, to the Micah Parsons effect and more.

Rams vs. 49ers Game Info

• When: Sunday, November 9, 2025 at 4:25 p.m. ET
• Where: Levi's Stadium in Santa Clara, California
• TV info: FOX
• Spread Favorite: Rams (-5.5)
• Moneyline: Rams (-250), 49ers (+205)
• Total: 49.5 points
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Rams Injuries

Jordan Whittington | WR (Questionable)

• Injury: Back
• Practice Status: Limited Participation in Practice

Puka Nacua | WR

• Injury: Chest
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 73 Targets | 61 Receptions | 711 Yards | 3 Touchdowns

AJ Jackson | OL

• Injury: Rest
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 1 Games Played

Byron Young | OLB

• Injury: Rest
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 9.0 Sacks | 9.0 Tackles for Loss | 41 Tackles | 0 Interceptions | 0 Passes Defended

Tyler Higbee | TE

• Injury: Rest
• Practice Status: Did Not Participate In Practice

Darious Williams | CB

• Injury: Shoulder
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 14 Tackles | 0 Interceptions | 7 Passes Defended

49ers Injuries

Mykel Williams | DL (Out)

• Injury: Knee
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 1.0 Sack | 4.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 0 Passes Defended

Ricky Pearsall | WR (Out)

• Injury: Knee
• Practice Status: Did Not Participate In Practice
• 2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 Touchdowns

Tatum Bethune | LB (Questionable)

• Injury: Thigh
• Practice Status: Limited Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 51 Tackles | 0 Interceptions | 1 Pass Defended

Keion White | DL (Questionable)

• Injury: Groin
• Practice Status: Limited Participation in Practice

Kalia Davis | DL (Questionable)

• Injury: Ankle
• Practice Status: Limited Participation in Practice

Alfred Collins | DT (Questionable)

• Injury: Hip
• Practice Status: Did Not Participate In Practice

Ben Bartch | OL (Questionable)

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2024 Season Stats: 1 Game Played

Dee Winters | LB (Questionable)

• Injury: Knee
• Practice Status: Limited Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 4.0 Tackles for Loss | 59 Tackles | 0 Interceptions | 3 Passes Defended

Brock Purdy | QB (Questionable)

• Injury: Toe
• Practice Status: Limited Participation in Practice
• 2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 Interceptions

Jake Brendel | OL

• Injury: Hamstring
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 3 Games Played

Trent Williams | OT

• Injury: Rest
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 4 Games Played

Christian McCaffrey | RB

• Injury: Rest
• Practice Status: Full Participation in Practice
• 2025 Rushing: 168 Attempts | 596 Yards | 4 Touchdowns
• 2025 Receiving Stats: 80 Targets | 61 Receptions | 626 Yards | 4 Touchdowns

Darrell Luter | CB

• Injury: Achilles
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 11 Tackles | 0 Interceptions | 0 Passes Defended

Mac Jones | QB

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Passing: 250-for-168 | 1,832 Yards | 10 Touchdowns | 5 Interceptions

Jauan Jennings | WR

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 41 Targets | 22 Receptions | 253 Yards | 2 Touchdowns

Bryce Huff | DL

• Injury: Hamstring
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 4.0 Sacks | 6.0 Tackles for Loss | 19 Tackles | 0 Interceptions | 1 Pass Defended

Rams vs. 49ers Head-to-Head History

• Los Angeles has a 3-2 record against San Francisco in their last five matchups.
• Los Angeles and San Francisco have matched up evenly on offense over their last five matchups, with each team producing 106 total points in those games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco 49ers

Los Angeles Rams