49ers vs. Falcons 2025 Prediction, Odds, Picks - Oct 19

The San Francisco 49ers (4-2) are favored by 1.5 points against the Atlanta Falcons (3-2) on October 19, 2025, starting at 8:20 p.m. ET, airing on NBC. The matchup has an over/under of 46.5 points.

Keep up with the 2025 NFL season on FOX Sports.

49ers vs. Falcons Odds & Betting Lines

49ers vs. Falcons Prediction & Pick

• Pick ATS: 49ers (-1.5)
  
• Pick OU: Under (46.5)
  
• Prediction: 49ers 24 - Falcons 17

How to Watch San Francisco vs. Atlanta

• Game date: Sunday, October 19, 2025
• Time: 8:20 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: NBC
• Live Boxscore: FOX Sports

49ers vs. Falcons Recent Matchups

• Atlanta owns a 2-1 record against San Francisco in their last three matchups.
• Over their last three head-to-head matchups, Atlanta has put up 70 points, while San Francisco has posted 67.

San Francisco Betting Info

• Against the spread, San Francisco is 3-3-0 this year.
• The 49ers have been favored by 1.5 points or more four times this season, and covered the spread in two of those games.
• San Francisco contests this year have eclipsed the over/under 66.7% of the time (four times in six games with a set point total).
• When playing as the moneyline favorite, the 49ers are 3-1, picking up a victory 75% of the time.
• The 49ers have a 53.5% chance to win this contest, based on the implied probability of the moneyline.

49ers Stats

San Francisco's Key Players

Offense

• On the ground, Christian McCaffrey averages 3.1 yards per attempt (43rd in the NFL) and 56 yards per game for 336 total rushing yards. He has recorded one rushing touchdown this season.
• McCaffrey has been targeted 60 times in the receiving game and has 46 catches (7.7 per game) for 444 yards (74 per game) and three TDs.
• Mac Jones has passed for 1,252 yards, six touchdowns and three interceptions this year. He averages 313 yards per game and 7.5 per attempt, while completing 67.3%.
• Through six games played, Jake Tonges is averaging 37.3 yards and 4.2 receptions per game on the way to 224 receiving yards and 25 catches. He's been targeted 34 times, and has three receiving touchdowns.
• Kendrick Bourne has 371 receiving yards without a touchdown with 23 catches on 33 targets. He's averaging 4.6 receptions and 74.2 yards per game.

Defense

• Over on the defensive side, Dee Winters has 40 tackles and three TFL in 2025.
• Marques Sigle has one TFL and 43 tackles.
• Bryce Huff has recorded 14 tackles, five TFL, and three sacks this year.
• So far this season, Upton Stout has 25 tackles, two TFL, and one sack.

Atlanta Betting Info

• Atlanta has covered the spread three times this year (3-2-0).
• This year, the Falcons have two ATS wins in three games as an underdog of 1.5 points or more.
• Games involving Atlanta have hit the over once this season.
• The Falcons have been underdogs in three games this season and won two (66.7%) of those contests.
• The moneyline for this contest implies a 51.2% chance of a victory for the Falcons.

Falcons Stats

Atlanta's Key Players

Offense

• Bijan Robinson has rushed for two touchdowns this year, and has accumulated 484 total rushing yards (96.8 per game and 5.8 per attempt).
• On top of his rushing statistics, Robinson has caught 24 passes (on 31 targets) for 338 yards (second on the Falcons), with one receiving touchdown. He's averaging 67.6 yards per game.
• Michael Penix Jr. has 1,168 passing yards, four touchdowns and three interceptions. His completion percentage is 62.4% and he averages 233.6 yards per game and 7.4 per attempt.
• He has also added 37 rushing yards (fourth on the Falcons), with one touchdown on the ground (averaging 7.4 yards per game and 2.5 per carry).
• This season, Drake London has caught 34 passes for 427 receiving yards with two touchdowns in the passing game. He has been targeted 53 total times and is averaging 6.8 receptions per game over five games played.
• Tyler Allgeier puts up 37.4 rushing yards per game through five games (187 total yards), with three rushing touchdowns.

Defense

• Kaden Elliss has 27 tackles, four TFL, 1.5 sacks, and one pass defended in 2025.
• Xavier Watts' stat sheet includes two interceptions (sixth in the NFL) as well as 27 tackles and four passes defended.
• During the 2025 campaign, DeAundre Alford has 16 tackles, one TFL, one sack, and one interception in four games.
• Divine Deablo's stat sheet includes 23 tackles, one TFL, 0.5 sacks, and four passes defended in five games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers

Atlanta Falcons