Yankees vs. White Sox Prediction, Odds, Picks - September 25

Aaron Judge and Chase Meidroth will look to continue their recent offensive production when the New York Yankees and Chicago White Sox meet at Yankee Stadium on Thursday, at 7:05 p.m. ET. The White Sox are +252 moneyline underdogs for this matchup against the favorite Yankees (-315). New York is favored on the run line (-1.5). An 8.5-run over/under has been set in this matchup.

Here's everything you need from a betting perspective on the Yankees-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Yankees Highlights | MLB on FOX

Enjoy the best moments between the Chicago White Sox and the New York Yankees.

Yankees vs. White Sox Game Information & Odds

• When: Thursday, September 25, 2025 at 7:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: YES and CHSN

Yankees vs. White Sox Prediction

• Score Prediction: Yankees 5, White Sox 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Yankees 59%, White Sox 41%

Yankees vs. White Sox Betting Insights

• The Yankees have won 80, or 59.3%, of the 135 games they've played as favorites this season.
• New York has a record of 2-1 in games when oddsmakers favor them by at least -315 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Yankees have a 75.9% chance to win.
• The White Sox have won in 57, or 36.8%, of the 155 contests they have been named as odds-on underdogs this year.
• This season, Chicago has been a moneyline underdog of -315 or longer four times, losing every contest.
• The moneyline set for this matchup implies the White Sox have a 28.4% chance of coming away with a victory in the contest.

Yankees Recent Betting Performance

• The Yankees have a 7-2 record across the nine games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups, the Yankees and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Yankees have a 5-5-0 record against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Judge paces the Yankees in home runs (51), runs batted in (109) and has accumulated a team-best batting average of .328.
• In all of Major League Baseball, Judge ranks fourth in home runs and sixth in RBI.
• Cody Bellinger is hitting .269 with 25 doubles, five triples, 29 home runs and 53 walks.
• Bellinger is 30th in home runs and 15th in RBI among all MLB hitters this season.
• Trent Grisham is hitting .237 with nine doubles, a triple, 34 home runs and 79 walks.
• Jazz Chisholm is batting .247 with 15 doubles, a triple, 31 home runs and 58 walks.
• Chisholm has recorded at least one hit in six straight games. In his last 10 outings he is hitting .256 with two doubles, two home runs, two walks and five RBIs.

Yankees Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in nine of their past 10 games and won one of those contests.
• In their last 10 games with a total, the White Sox and their opponents are 3-7-0 when it comes to hitting the over.
• The White Sox have five wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas has 32 doubles, two triples, 15 home runs and 53 walks while batting .231.
• Vargas' home run total places him 138th in the majors, and he is 133rd in RBI.
• Vargas takes a hitting streak of five games into this game. In his last five games he is batting .333 with a double, a home run, three walks and four RBIs.
• Lenyn Sosa's 21 home runs, 72 runs batted in and .259 batting average are all tops in the lineup.
• Sosa ranks 67th in home runs and 77th in RBI among all hitters in the big leagues.
• Meidroth is hitting .260 with 15 doubles, five home runs and 45 walks.
• Edgar Quero has 17 doubles, five home runs and 31 walks while hitting .272.

White Sox Team Props

White Sox vs. Yankees Highlights | MLB on FOX

Enjoy the best moments between the Chicago White Sox and the New York Yankees.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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