Yankees vs. White Sox Prediction, Odds, Picks - September 24

Fraser Ellard takes the mound for the Chicago White Sox on Wednesday at Yankee Stadium against Ben Rice and the New York Yankees. First pitch is at 7:05 p.m. ET. The Yankees are -383 moneyline favorites in this matchup with the White Sox (+303). New York (-1.5) is the favorite on the run line. The total is 8 runs for the game.

Take a look at everything you need from a betting perspective on the Yankees-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Yankees vs. White Sox Game Information & Odds

• When: Wednesday, September 24, 2025 at 7:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: YES and CHSN

Yankees vs. White Sox Prediction

• Score Prediction: Yankees 5, White Sox 3
• Total Prediction: Over 8 runs
• Win Probabilities: Yankees 60%, White Sox 40%

Yankees vs. White Sox Betting Insights

• This season, the Yankees have won 79 out of the 134 games, or 59%, in which they've been favored.
• New York has not entered a game this season with shorter moneyline odds than -383.
• Sportsbooks have implied with the moneyline set for this matchup that the Yankees have a 79.3% chance to win.
• The White Sox have been chosen as underdogs in 154 games this year and have walked away with the win 57 times (37%) in those games.
• Oddsmakers have given Chicago the worst odds of winning it has seen this season with a +303 moneyline listed for this contest.
• The White Sox have an implied victory probability of 24.8% according to the moneyline set by sportsbooks for this matchup.

Yankees Recent Betting Performance

• The Yankees went 7-2 across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Yankees combined with their opponents to hit the over on the run total three times.
• The Yankees are 5-5-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Not only does Aaron Judge lead the Yankees in hitting with his .325 average, he also is their premier power option with 49 home runs and 105 RBI.
• Of all batters in the majors, Judge's home run total ranks him fourth, and his RBI tally ranks him ninth.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 52 walks while batting .269.
• Bellinger ranks 30th in homers and 15th in RBI on the year.
• Trent Grisham is batting .236 with nine doubles, a triple, 33 home runs and 77 walks.
• Jazz Chisholm is hitting .247 with 14 doubles, a triple, 31 home runs and 58 walks.
• Chisholm takes a five-game streak with at least one hit into this one. During his last five outings he is batting .412 with a double, two home runs, two walks and four RBIs.

Yankees Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in nine of their past 10 games and won one of those contests.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over eight times.
• The White Sox have a record of 5-5-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .230 with 32 doubles, two triples, 15 home runs and 52 walks, while getting on base at a rate of .311.
• Vargas is 137th in homers and 133rd in RBI among all hitters in the majors.
• Vargas carries a four-game hitting streak into this matchup. In his last five games he is batting .263 with a double, a home run, two walks and four RBIs.
• Lenyn Sosa's 21 home runs, 71 runs batted in and .258 batting average are all tops in the lineup.
• Among all MLB hitters, Sosa is 67th in homers and 79th in RBI.
• Chase Meidroth is hitting .262 with 15 doubles, five home runs and 45 walks.
• Mike Tauchman is batting .263 with 17 doubles, a triple, nine home runs and 45 walks.

White Sox Team Props

White Sox vs. Yankees Highlights | MLB on FOX

Enjoy the best moments between the Chicago White Sox and the New York Yankees.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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