Tigers vs. Guardians Prediction, Odds, Picks - September 18

Tarik Skubal takes the mound for the Detroit Tigers on Thursday at Comerica Park against Jose Ramirez and the Cleveland Guardians. First pitch is at 1:10 p.m. ET for the final game of a three-game series. Oddsmakers list the Tigers as -235 favorites on the moneyline, while giving the underdog Guardians +192 moneyline odds to win. Detroit is the favorite on the run line (-1.5). The total for the contest has been set at 7 runs.

Take a look at everything you need from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and Detroit Tigers.

Tigers vs. Guardians Game Information & Odds

• When: Thursday, September 18, 2025 at 1:10 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: FDSDET and CLEG

Tigers vs. Guardians Prediction

• Score Prediction: Tigers 4, Guardians 3
• Total Prediction: Over 7 runs
• Win Probabilities: Tigers 56%, Guardians 44%

Tigers vs. Guardians Betting Insights

• This season, the Tigers have won 63 out of the 106 games, or 59.4%, in which they've been favored.
• Detroit is 12-1 this season when entering a game favored by -235 or more on the moneyline.
• The oddsmakers' moneyline implies a 70.1% chance of a victory for the Tigers.
• The Guardians have been chosen as underdogs in 84 games this year and have walked away with the win 39 times (46.4%) in those games.
• Cleveland has yet to win this season when listed as an underdog of +192 or worse on the moneyline this season.
• The moneyline set for this matchup implies the Guardians have a 34.2% chance of walking away with the win.

Tigers Recent Betting Performance

• The Tigers played as the moneyline favorite in seven of their last 10 games, and finished 2-5 in those matchups.
• In their last 10 outings (all had set totals), the Tigers combined with their opponents to hit the over on the run total seven times.
• The Tigers' record against the spread is 4-6-0 over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres is hitting .252 with 21 doubles, 16 home runs and 82 walks.
• In all of Major League Baseball, Torres is 117th in home runs and 65th in RBI.
• Riley Greene has hit 34 home runs with 108 runs batted in while batting .263. Those stats are all team-highs.
• Of all major league hitters, Greene is 10th in home runs and fifth in RBI.
• Spencer Torkelson is batting .240 with 26 doubles, a triple, 29 home runs and 68 walks.
• Kerry Carpenter is batting .259 with 18 doubles, five triples, 26 home runs and 18 walks.
• Carpenter brings a two-game streak with at least one hit into this one. In his last five games he is hitting .400 with two home runs, a walk and three RBIs.

Tigers Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs three times over their past 10 games and won each of those contests.
• When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
• Over their last 10 games, the Guardians are 8-2-0 against the spread.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the Guardians in home runs (28), runs batted in (78) and has recorded a team-high batting average of .281.
• Among all hitters in MLB, Ramirez's home run total ranks 31st and his RBI tally ranks 47th.
• Steven Kwan is hitting .275 with 27 doubles, a triple, 10 home runs and 53 walks.
• Kwan ranks 204th in home runs and 169th in RBI among all hitters in the big leagues.
• Kyle Manzardo has 17 doubles, two triples, 26 home runs and 47 walks while batting .241.
• Angel Martinez is batting .230 with 22 doubles, two triples, 11 home runs and 19 walks.

Guardians Team Props

Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and Detroit Tigers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

Cleveland Guardians