Tigers vs. Guardians Prediction, Odds, Picks - September 16

Parker Meadows and the Detroit Tigers will play Steven Kwan and the Cleveland Guardians at Comerica Park in the first of a three-game series, on Tuesday at 6:40 p.m. ET. The favored Tigers have -144 moneyline odds against the underdog Guardians, who are listed at +121. Detroit (-1.5) is the favorite on the run line. The over/under for the contest has been set at 8 runs.

Check out everything you need from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Guardians Game Information & Odds

• When: Tuesday, September 16, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: FDSDET and CLEG

Tigers vs. Guardians Prediction

• Score Prediction: Tigers 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Tigers 55%, Guardians 45%

Tigers vs. Guardians Betting Insights

• The Tigers have entered the game as favorites 104 times this season and won 63, or 60.6%, of those games.
• Detroit has a record of 43-20 in games when bookmakers favor them by at least -144 on the moneyline.
• The sportsbooks' moneyline implies a 59% chance of a victory for the Tigers.
• The Guardians have been underdogs in 82 games this season and have come away with the win 37 times (45.1%) in those contests.
• This season, Cleveland has come away with a win 20 times in 37 chances when named as an underdog of at least +121 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 45.2% chance of coming away with a victory in the contest.

Tigers Recent Betting Performance

• The Tigers went 2-4 across the six games they were moneyline favorites in their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Tigers and their opponents combined to hit the over on the total seven times.
• The Tigers have gone 5-5-0 against the spread over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres has 21 doubles, 15 home runs and 82 walks while hitting .255.
• In all of the majors, Torres is 129th in home runs and 66th in RBI.
• Riley Greene has shown his power as he paces his team with 34 home runs and 108 runs batted in, with a team-high .265 batting average.
• Greene is ninth in home runs and fifth in RBI among all major league hitters this season.
• Spencer Torkelson is batting .237 with 26 doubles, a triple, 28 home runs and 68 walks.
• Torkelson is on a two-game hitting streak entering this contest. During his last five outings he is hitting .316 with three walks.
• Zach McKinstry is batting .261 with 21 doubles, 11 triples, 11 home runs and 45 walks.

Tigers Team Props

Guardians Recent Betting Performance

• In three games as an underdog over the last 10 matchups, Cleveland has a perfect record of 3-0.
• The Guardians and their opponents have combined to hit the over two times in their last 10 games with a total.
• The Guardians have won eight of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the squad with a batting average of .281, and paces the Guardians in home runs, with 28 and runs batted in with 77.
• In all of the big leagues, Ramirez ranks 25th in homers and 48th in RBI.
• Kwan has 26 doubles, a triple, 10 home runs and 52 walks while batting .273.
• Kwan ranks 197th in home runs and 174th in RBI among all hitters in the big leagues.
• Kyle Manzardo has 15 doubles, two triples, 26 home runs and 46 walks while hitting .236.
• Angel Martinez is hitting .227 with 22 doubles, a triple, 11 home runs and 19 walks.

Guardians Team Props

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Check out the best moments between the Detroit Tigers and the Miami Marlins!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

Cleveland Guardians