Reds vs. Pirates Prediction, Odds, Picks - May 21

The Pittsburgh Pirates and Oneil Cruz hit the field at PNC Park against Elly De La Cruz and the Cincinnati Reds on Wednesday. The Pirates are +110 moneyline underdogs in this matchup with the favored Reds (-129). Cincinnati is a 1.5-run favorite (at +134 odds). The over/under is 8 runs for the contest.

Check out everything you need to know from a betting perspective on the Reds-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Pittsburgh Pirates.

Reds vs. Pirates Game Information & Odds

• When: Wednesday, May 21, 2025 at 12:35 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and FDSOH

Reds vs. Pirates Prediction

• Score Prediction: Reds 5, Pirates 4
• Total Prediction: Under 8 runs
• Win Probabilities: Reds 51%, Pirates 49%

Reds vs. Pirates Betting Insights

• The Reds have been favorites in 25 games this season and won 13 (52%) of those contests.
• Cincinnati is 8-6 this season when entering a game favored by -129 or more on the moneyline.
• The oddsmakers' moneyline implies a 56.3% chance of a victory for the Reds.
• The Pirates have been underdogs in 33 games this season and have come away with the win 11 times (33.3%) in those contests.
• Pittsburgh has a mark of 9-18 in contests where oddsmakers favor it by +110 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Pirates have a 47.6% chance of pulling out a win.

Reds Recent Betting Performance

• The Reds went 3-3 across the six games they were moneyline favorites in their last 10 matchups.
• In their last 10 outings (all had set totals), the Reds combined with their opponents to hit the over on the total one time.
• The Reds have gone 6-4-0 against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• De La Cruz leads the Reds in home runs (eight) and runs batted in (33).
• Including all MLB hitters, De La Cruz is 97th in batting average, 99th in on-base percentage, and 88th in slugging.
• TJ Friedl has eight doubles, two triples, three home runs and 23 walks while hitting .280.
• Friedl is 177th in home runs in baseball, and 123rd in RBI.
• Friedl carries a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .333 with two doubles, a triple, three walks and an RBI.
• Gavin Lux leads the Reds with a .294 batting average.
• Austin Hays has six doubles, six home runs and seven walks while batting .319.

Reds Team Props

Pirates Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Pirates have a record of 3-6.
• In their last 10 games with a total, the Pirates and their opponents are 1-7-2 when it comes to hitting the over.
• The Pirates have a record of 6-4-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Cruz leads the Pirates with eight long balls.
• Cruz is 41st in home runs and 123rd in RBI among all hitters in MLB.
• Andrew McCutchen is hitting .243 with seven doubles, three home runs and 20 walks.
• McCutchen ranks 177th in home runs and 182nd in RBI among all hitters in the majors.
• Bryan Reynolds has a team-high 23 runs batted in.
• Isiah Kiner-Falefa has three doubles, a triple, a home run and eight walks while batting .282.

Pirates Team Props

Reds vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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