Reds vs. Giants Prediction, Odds, Picks - March 27

The Cincinnati Reds and San Francisco Giants will send Hunter Greene and Logan Webb to the hill, respectively, on Opening Day at Great American Ball Park. First pitch is at 4:10 p.m. ET. The Giants are -109 moneyline underdogs for this matchup with the favored Reds (-110). San Francisco (-1.5) is favored on the run line. A 7.5-run total has been set for this contest.

Take a look at everything you need to know from a betting perspective on the Reds-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Houston Astros vs. Cincinnati Reds Highlights | MLB on FOX

Check out the highlights as the Houston Astros took on the Cincinnati Reds in this regular season matchup.

Reds vs. Giants Game Information & Odds

• When: Thursday, March 27, 2025 at 4:10 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to Watch on TV: FDSOH and NBCS-BA

Reds vs. Giants Prediction

• Score Prediction: Reds 5, Giants 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Reds 55%, Giants 45%

Reds vs. Giants Betting Insights

• The Reds finished with a 36-31 record in games they were listed as the moneyline favorite last season (winning 53.7% of those games).
• In games it played as a moneyline favorite with odds of -110 or shorter last year, Cincinnati had a record of 37-33 (52.9%).
• Based on this game's moneyline, the Reds have an implied win probability of 52.4%.
• The Giants were underdogs 78 times last season and won 33, or 42.3%, of those games.

Reds Player Insights

• Elly De La Cruz hit 25 home runs last season while also driving in 76 runs.
• Spencer Steer was a key run producer with a .225 average, 20 homers and 92 RBI.
• Gavin Lux finished last season with 10 home runs, 50 RBI and a batting average of .251.
• Jeimer Candelario hit .225 with an OBP of .279, and a slugging percentage of .429.

Reds Team Props

Giants Player Insights

• Willy Adames racked up 32 home runs and had 112 runs batted in last season.
• Matt Chapman had 39 doubles, two triples, 27 home runs and 64 walks while hitting .247.
• Heliot Ramos racked up 128 hits with a batting average of .269 last season.
• Mike Yastrzemski had 16 doubles, nine triples, 18 home runs and 38 walks while batting .231.

Giants Team Props

Houston Astros vs. Cincinnati Reds Highlights | MLB on FOX

Check out the highlights as the Houston Astros took on the Cincinnati Reds in this regular season matchup.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Cincinnati Reds

San Francisco Giants