Red Sox vs. Mets Prediction, Odds, Picks - May 21

The Boston Red Sox versus New York Mets game on Wednesday at 6:45 p.m. ET will showcase a pair of hot hitters in Rafael Devers and Pete Alonso. Bookmakers list the Red Sox as -152 moneyline favorites, while giving the underdog Mets +127 moneyline odds. Boston is favored on the run line (-1.5 with +144 odds). The total for the matchup is set at 7.5 runs.

Check out everything you need from a betting perspective on the Red Sox-Mets game, regarding the run line, moneyline and total, plus expert picks.

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Mets vs. Red Sox Highlights | MLB on FOX

Check out the top moments from this MLB game between the New York Mets and the Boston Red Sox!

Red Sox vs. Mets Game Information & Odds

• When: Wednesday, May 21, 2025 at 6:45 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: MLB Network, NESN, and SNY

Red Sox vs. Mets Prediction

• Score Prediction: Mets 4, Red Sox 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Red Sox 50%, Mets 50%

Red Sox vs. Mets Betting Insights

• This season, the Red Sox have won 18 out of the 34 games, or 52.9%, in which they've been favored.
• This season Boston has won five of its 11 games, or 45.5%, when favored by at least -152 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Red Sox have a 60.3% chance to win.
• The Mets have been chosen as underdogs in 13 games this year and have walked away with the win six times (46.2%) in those games.
• New York has played as an underdog of +127 or more just one time this year and came away with a loss in that game.
• The moneyline set for this matchup implies the Mets have a 44.1% chance of walking away with the win.

Red Sox Recent Betting Performance

• The Red Sox played as the moneyline favorite for three of their last 10 games, and they finished 1-2 in those matchups.
• Over their last 10 matchups, the Red Sox and their opponents combined to go over the run total six times (all 10 of the games had set totals).
• The Red Sox have a 6-4-0 record against the spread over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Alex Bregman's .304 average and 11 homers both put him atop the Red Sox leaderboard this season.
• Among all MLB batters, Bregman ranks 18th in batting average, 16th in on-base percentage, and eighth in slugging.
• Bregman carries a two-game hitting streak into this matchup. During his last five outings he is hitting .188 with two doubles, three walks and two RBIs.
• Devers' 39 runs batted in are a team-high mark.
• Devers is 19th in homers and fourth in RBI among all major league hitters this year.
• Wilyer Abreu has hit a team-best 11 home runs.
• Abreu will look to build on his two-game hitting in this game. In his last five games he is batting .125 with a double.
• Jarren Duran has 11 doubles, six triples, three home runs and 13 walks while batting .264.

Red Sox Team Props

Mets Recent Betting Performance

• The Mets have played as underdogs in three of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Mets and their opponents have failed to hit the over eight times.
• The Mets have won two of their last 10 games against the spread.

Mets Recent Stats

Mets Player Insights

• Alonso paces the Mets in home runs (nine), runs batted in (37) and has put up a team-best batting average of .294.
• Among all hitters in the majors, Alonso's home run total ranks 33rd and his RBI tally is eighth.
• Juan Soto has nine doubles, eight home runs and 38 walks while hitting .247.
• Among all MLB hitters, Soto is 43rd in home runs and 105th in RBI.
• Francisco Lindor has nine home runs, tops in the clubhouse.
• Brandon Nimmo has nine doubles, eight home runs and 15 walks while batting .215.

Mets Team Props

Mets vs. Red Sox Highlights | MLB on FOX

Check out the top moments from this MLB game between the New York Mets and the Boston Red Sox!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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