Rays vs. Orioles Prediction, Odds, Picks - September 23

Dylan Beavers and Chandler Simpson take the field when the Baltimore Orioles and Tampa Bay Rays meet on Tuesday at Oriole Park at Camden Yards. The Rays are listed as -111 moneyline favorites in this matchup with the Orioles (-108). Tampa Bay is a 1.5-run favorite (at +145 odds). The matchup's over/under has been listed at 8.5 runs.

Here's everything you need from a betting perspective on the Rays-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Rays vs. Orioles Game Information & Odds

• When: Tuesday, September 23, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN2 and FDSSUN

Rays vs. Orioles Prediction

• Score Prediction: Rays 6, Orioles 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Rays 50%, Orioles 50%

Rays vs. Orioles Betting Insights

• This season, the Rays have been favored 78 times and won 44, or 56.4%, of those games.
• Tampa Bay has entered 73 games this season favored by -111 or more and is 43-30 in those contests.
• The Rays have a 52.6% chance to win this game based on the implied probability of the moneyline.
• The Orioles have come away with 40 wins in the 89 contests they have been listed as the underdogs in this season.
• Baltimore has a win-loss record of 39-49 when favored by -108 or worse by oddsmakers this year.
• The Orioles have an implied victory probability of 51.9% according to the moneyline set for this matchup.

Rays Recent Betting Performance

• The Rays went 1-2 over the three games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all had set totals), the Rays combined with their opponents to go over the run total six times.
• The Rays have put together a 6-4-0 record against the spread over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Junior Caminero leads the Rays in home runs (44) and runs batted in (108).
• Of all hitters in the majors, Caminero is sixth in home runs and sixth in RBI.
• Yandy Diaz is hitting .302 to pace his team.
• Diaz is 45th in homers and 33rd in RBI on the season.
• Diaz enters this game looking for his fourth game in a row with a hit. In his last five games he is hitting .533 with a double, a home run, six walks and three RBIs.
• Brandon Lowe is batting .258 with 18 doubles, 30 home runs and 37 walks.
• Lowe will look to build on his four-game hitting in this matchup. In his last five games he is hitting .238 with two home runs, a walk and six RBIs.
• Simpson is batting .299 with 14 doubles, three triples and 20 walks.

Rays Team Props

Orioles Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Orioles have a record of 2-6.
• In their last 10 games with a total, the Orioles and their opponents have failed to hit the over seven times.
• The Orioles have four wins against the spread in their last 10 chances.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson has recorded a team-best batting average of .273 and paces the Orioles in runs batted in with a mark of 65.
• Among all hitters in MLB, Henderson's home run total is 122nd and his RBI tally ranks 97th.
• Jackson Holliday has put up a team-high 17 home runs.
• Among all major league hitters, Holliday is 109th in home runs and 139th in RBI.
• Jordan Westburg is batting .260 with nine doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman has 16 doubles, a triple, nine home runs and 37 walks while hitting .227.

Orioles Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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