Rays vs. Guardians Prediction, Odds, Picks - August 27

Junior Caminero and the Tampa Bay Rays will see Slade Cecconi on the mound for the Cleveland Guardians on Wednesday at 1:10 p.m. ET. The favored Rays have -148 moneyline odds against the underdog Guardians, who are listed at +124. Tampa Bay is favored on the run line (-1.5). The total for the matchup is listed at 7 runs.

Take a look at everything you need to know from a betting perspective on the Rays-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Rays vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and the Cleveland Guardians.

Rays vs. Guardians Game Information & Odds

• When: Wednesday, August 27, 2025 at 1:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: MLB Network, CLEG, and FDSSUN

Rays vs. Guardians Prediction

• Score Prediction: Guardians 5, Rays 4
• Total Prediction: Over 7 runs
• Win Probabilities: Rays 50%, Guardians 50%

Rays vs. Guardians Betting Insights

• The Rays have won 37, or 58.7%, of the 63 games they've played as favorites this season.
• Tampa Bay has a record of 9-11, a 45% win rate, when favored by -148 or more by oddsmakers this season.
• The oddsmakers' moneyline implies a 59.7% chance of a victory for the Rays.
• The Guardians have been chosen as underdogs in 71 games this year and have walked away with the win 30 times (42.3%) in those games.
• This season, Cleveland has come away with a win 13 times in 27 chances when named as an underdog of at least +124 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 44.6% chance of walking away with the win.

Rays Recent Betting Performance

• The Rays were favored on the moneyline in four of their last 10 games, and they went 3-1 in those matchups.
• In their last 10 matchups, the Rays and their opponents combined to go over the run total seven times (all 10 of the games had set totals).
• The Rays are 4-6-0 against the spread over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Caminero has a team-best 39 home runs and 94 runs batted in.
• Of all hitters in baseball, Caminero's home run total ranks him sixth, and his RBI tally ranks him sixth.
• Yandy Diaz is batting .284 with 24 doubles, a triple, 22 home runs and 40 walks.
• Including all MLB hitters, Diaz is 40th in homers and 31st in RBI.
• Diaz carries a two-game streak with at least one hit into this contest. In his last five games he is hitting .333 with two doubles, two home runs and three RBIs.
• Brandon Lowe is hitting .263 with 13 doubles, 25 home runs and 32 walks.
• Chandler Simpson is batting .302 with 11 doubles, three triples and 18 walks.

Rays Team Props

Guardians Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Guardians have a record of 1-5.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over six times.
• The Guardians are 4-6-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the squad with a batting average of .284, while leading the Guardians in home runs, with 26 and runs batted in with 68.
• Ramirez's home run total puts him 19th in the big leagues, and he is 50th in RBI.
• Steven Kwan has 22 doubles, a triple, 10 home runs and 43 walks while hitting .271.
• Among all major league hitters, Kwan ranks 175th in homers and 186th in RBI.
• Kyle Manzardo is batting .232 with 14 doubles, two triples, 21 home runs and 40 walks.
• Angel Martinez is hitting .227 with 21 doubles, a triple, 10 home runs and 16 walks.

Guardians Team Props

Rays vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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