Pirates vs. Orioles Prediction, Odds, Picks - September 10

Bryan Reynolds and the Pittsburgh Pirates will play Gunnar Henderson and the Baltimore Orioles on Wednesday at Oriole Park at Camden Yards, at 6:35 p.m. ET. The Pirates are the favorite in this one, at -158, while the underdog Orioles have +133 odds to win. Pittsburgh is the run-line favorite (-1.5). A 7-run total is listed for this contest.

Here is everything you need to know from a betting perspective on the Pirates-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Orioles Game Information & Odds

• When: Wednesday, September 10, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and SportsNet PT

Pirates vs. Orioles Prediction

• Score Prediction: Orioles 4, Pirates 3
• Total Prediction: Under 7 runs
• Win Probabilities: Pirates 54%, Orioles 46%

Pirates vs. Orioles Betting Insights

• This season, the Pirates have won 20 out of the 39 games, or 51.3%, in which they've been favored.
• Pittsburgh has a record of 6-3 in games when sportsbooks favor them by at least -158 on the moneyline.
• The Pirates have a 61.2% chance to win this game based on the implied probability of the moneyline.
• The Orioles have come away with 37 wins in the 80 contests they have been listed as the underdogs in this season.
• This season, Baltimore has come away with a win nine times in 21 chances when named as an underdog of at least +133 or worse on the moneyline.
• The Orioles have an implied victory probability of 42.9% according to the moneyline set by oddsmakers for this matchup.

Pirates Recent Betting Performance

• The Pirates have not been the moneyline favorite in the last 10 games.
• In their last 10 outings -- all had a set run total -- the Pirates and their opponents combined to go over the total four times.
• The Pirates' record against the spread is 6-4-0 over their past 10 games.

Pirates Recent Stats

Pirates Player Insights

• Reynolds leads the Pirates with 70 runs batted in while racking up a team-high batting average of .246.
• Reynolds' home runs rank him 124th in the majors, and he ranks 63rd in RBI.
• Oneil Cruz's 19 home runs pace his team.
• Cruz ranks 74th in home runs and 117th in RBI among all hitters in baseball.
• Andrew McCutchen is hitting .243 with 22 doubles, 13 home runs and 61 walks.
• McCutchen will look to build on his two-game hitting in this game. In his last five games he is hitting .158 with a double, a home run, a walk and two RBIs.
• Tommy Pham has 17 doubles, a triple, nine home runs and 40 walks while hitting .261.

Pirates Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in eight of their past 10 games and have gone 5-3 in those contests.
• When it comes to hitting the over, the Orioles and their opponents are 4-5-1 in their last 10 games with a total.
• The Orioles are 6-4-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• Henderson has recorded a team-best batting average of .272 while pacing the Orioles in runs batted in with a mark of 61.
• Henderson ranks 109th in homers and 96th in RBI among all batters in the majors.
• Jackson Holliday has hit a team-best 17 home runs.
• Holliday ranks 96th among all hitters in MLB in homers, and 135th in RBI.
• Ryan Mountcastle is batting .259 with 18 doubles, five home runs and 14 walks.
• Colton Cowser is hitting .206 with 12 doubles, 13 home runs and 19 walks.

Orioles Team Props

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Check out the best highlights between the Los Angeles Dodgers and Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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