Padres vs. Royals Prediction, Odds, Picks - June 21

The San Diego Padres and Kansas City Royals will meet on Saturday at PETCO Park, at 7:15 p.m. ET, with Fernando Tatis Jr. and Maikel Garcia among those expected to step up at the plate. The Royals are +133 moneyline underdogs for this matchup against the favorite Padres (-159). San Diego is a 1.5-run favorite (at +139 odds). A 7.5-run over/under is set for this game.

Check out everything you need to know from a betting perspective on the Padres-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Royals Game Information & Odds

• When: Saturday, June 21, 2025 at 7:15 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: FOX

Padres vs. Royals Prediction

• Score Prediction: Padres 4, Royals 3
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 54%, Royals 46%

Padres vs. Royals Betting Insights

• The Padres have been favorites in 37 games this season and won 22 (59.5%) of those contests.
• San Diego has a record of 11-7, a 61.1% win rate, when favored by -159 or more by sportsbooks this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Padres have a 61.4% chance to win.
• The Royals have won in 23, or 51.1%, of the 45 contests they have been named as odds-on underdogs this year.
• Kansas City has a win-loss record of 7-3 when favored by +133 or worse by sportsbooks this year.
• The moneyline set for this matchup implies the Royals have a 42.9% chance of coming away with a victory in the contest.

Padres Recent Betting Performance

• In the last 10 games, the Padres were listed as the moneyline favorite by bookmakers only two times, and they split those games.
• Over their last 10 outings, the Padres and their opponents combined to hit the over on the run total five times (all 10 games had set totals).
• The Padres' ATS record is 5-5-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Manny Machado comes into Saturday's game hitting .311 with 46 RBI, both team-leading marks for the Padres. He has also connected on 12 long balls in 2025.
• Among all hitters in the majors, Machado is 43rd in homers and 24th in RBI.
• Machado carries a two-game hitting streak into this matchup. During his last five outings he is batting .250 with a double, two home runs, two walks and three RBIs.
• Tatis' 13 home runs pace his team.
• Tatis is 33rd in home runs in the majors, and 103rd in RBI.
• Luis Arraez has 16 doubles, four triples, three home runs and 13 walks while hitting .280.
• Arraez has at least one base hit in seven games in a row. In his last 10 games he is batting .311 with three doubles, a triple, a walk and four RBIs.
• Gavin Sheets is batting .266 with 10 doubles, a triple, 12 home runs and 20 walks.
• Sheets is riding an 11-game hitting streak into this one. In his last 10 games he is batting .361 with three doubles, a home run, five walks and seven RBIs.

Padres Team Props

Royals Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Royals have a record of 3-3.
• In their last 10 games with a total, the Royals and their opponents are 5-5-0 when it comes to hitting the over.
• The Royals have a record of 5-5-0 ATS over their last 10 games.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. is hitting .284 with 25 doubles, three triples, 10 home runs and 26 walks, while getting on base at a rate of .342.
• Witt is 67th in home runs and 46th in RBI among all hitters in the big leagues.
• Witt has collected a hit in five games in a row. In his last five games he is batting .400 with three doubles, two home runs, two walks and three RBIs.
• Garcia has a club-best .319 batting average.
• Garcia is 111th in homers and 74th in RBI among all major league batters this year.
• Vinnie Pasquantino has been a significant run producer for the Royals with 11 home runs and 41 runs batted in.
• Jonathan India has 13 doubles, four home runs and 28 walks while hitting .245.

Royals Team Props

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