Padres vs. Pirates Prediction, Odds, Picks - June 1

Fernando Tatis Jr. and Bryan Reynolds will be among the star attractions when the San Diego Padres face the Pittsburgh Pirates on Sunday at 5:10 p.m. ET, at PETCO Park. The Padres are the favorite in this one, at -229, while the underdog Pirates have +188 odds to upset. San Diego is the run-line favorite (-1.5). A 7.5-run over/under is listed for the matchup.

Here's everything you need from a betting perspective on the Padres-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Pittsburgh Pirates and the San Diego Padres!

Padres vs. Pirates Game Information & Odds

• When: Sunday, June 1, 2025 at 5:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and SportsNet PT

Padres vs. Pirates Prediction

• Score Prediction: Padres 5, Pirates 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 56%, Pirates 44%

Padres vs. Pirates Betting Insights

• This season, the Padres have won 20 out of the 33 games, or 60.6%, in which they've been favored.
• San Diego has entered four games this season favored by -229 or more and is 2-2 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 69.6% chance to win.
• The Pirates have been victorious in 16, or 38.1%, of the 42 contests they have been chosen as underdogs in this season.
• This year, Pittsburgh has won three of eight games when listed as at least +188 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Pirates have a 34.7% chance of pulling out a win.

Padres Recent Betting Performance

• The Padres have a 3-3 record from the six games they were moneyline favorites over their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Padres and their opponents combined to go over the run total four times.
• The Padres are 3-7-0 against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis has gone yard 13 times this season, the highest mark on the Padres, while hitting .269 with 28 RBI.
• Tatis' home runs put him 13th in MLB, and he is 73rd in RBI.
• Manny Machado is batting .308 to pace his team.
• Of all MLB batters, Machado ranks 110th in homers and 93rd in RBI.
• Luis Arraez has 10 doubles, three triples, three home runs and 10 walks while hitting .285.
• Gavin Sheets has racked up 34 runs batted in to pace his team.

Padres Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in nine of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Pirates and their opponents have combined to hit the over five times.
• The Pirates have a record of 7-3-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Oneil Cruz has a team-best 12 home runs.
• Among all hitters in MLB, Cruz's home run total is 19th and his RBI tally is 84th.
• Reynolds has put up 34 runs batted in to lead his team.
• Among all MLB hitters, Reynolds ranks 86th in homers and 29th in RBI.
• Andrew McCutchen leads the Pirates with a team-best batting average of .265.
• Isiah Kiner-Falefa has nine doubles, a triple, a home run and nine walks while batting .304.

Pirates Team Props

Pirates vs. Padres Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the San Diego Padres!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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