Padres vs. Giants Prediction, Odds, Picks - August 20

Landen Roupp gets the nod on the mound for the San Francisco Giants looking to shut down Fernando Tatis Jr. and the San Diego Padres on Wednesday at 9:40 p.m. ET. The Giants have been listed as +119 moneyline underdogs for this matchup with the favorite Padres (-142). San Diego is favored on the run line (-1.5). The over/under for the matchup is set at 8 runs.

Take a look at everything you need to know from a betting perspective on the Padres-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Giants Game Information & Odds

• When: Wednesday, August 20, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: MLB Network, SDPA, and NBCS-BA

Padres vs. Giants Prediction

• Score Prediction: Padres 5, Giants 4
• Total Prediction: Over 8 runs
• Win Probabilities: Padres 55%, Giants 45%

Padres vs. Giants Betting Insights

• This season, the Padres have won 41 out of the 68 games, or 60.3%, in which they've been favored.
• San Diego has entered 41 games this season favored by -142 or more and is 25-16 in those contests.
• The bookmakers' moneyline implies a 58.7% chance of a victory for the Padres.
• The Giants have won in 23, or 46.9%, of the 49 contests they have been named as odds-on underdogs this year.
• This year, San Francisco has won 10 of 21 games when listed as at least +119 or worse on the moneyline.
• The moneyline set for this matchup implies the Giants have a 45.7% chance of coming away with a victory in the contest.

Padres Recent Betting Performance

• The Padres were the moneyline favorite in five of their last 10 games, and they finished 4-1 in those matchups.
• In their last 10 matchups, the Padres and their opponents combined to hit the over on the run total four times (all 10 games had set totals).
• The Padres have a 7-3-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Manny Machado has racked up a team-high batting average of .292, while leading the Padres in home runs (20) and runs batted in (73).
• Including all MLB hitters, Machado ranks 15th in batting average, 36th in on-base percentage, and 33rd in slugging.
• Machado takes a hitting streak of two games into this matchup. In his last five games he is batting .200 with a double, a walk and an RBI.
• Tatis is batting .264 with 23 doubles, two triples, 17 home runs and 73 walks.
• Tatis ranks 71st in home runs in baseball, and 108th in RBI.
• Luis Arraez is hitting .290 with 27 doubles, four triples, six home runs and 26 walks.
• Arraez is on a four-game hitting streak entering this contest. In his last five games he is hitting .300 with four doubles, a walk and two RBIs.
• Xander Bogaerts is hitting .262 with 28 doubles, 10 home runs and 47 walks.

Padres Team Props

Giants Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Giants have a record of 1-3.
• In their last 10 games with a total, the Giants and their opponents have failed to hit the over seven times.
• Over their last 10 games, the Giants are 3-7-0 against the spread.

Giants Recent Stats

Giants Player Insights

• Rafael Devers paces the Giants with 24 home runs and runs batted in, driving in 82.
• Devers ranks 26th in home runs and 13th in RBI among all hitters in MLB.
• Jung Hoo Lee has 29 doubles, 10 triples, seven home runs and 39 walks while batting .262.
• Lee is 230th in homers and 132nd in RBI among all batters in MLB.
• Willy Adames is hitting .222 with 18 doubles, two triples, 19 home runs and 57 walks.
• Heliot Ramos paces the Giants with a team-leading batting average of .265.

Giants Team Props

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