Orioles vs. White Sox Prediction, Odds, Picks - September 15

Jackson Holliday and the Baltimore Orioles will play Andrew Benintendi and the Chicago White Sox on Monday at Rate Field, at 7:40 p.m. ET. The Orioles have been listed as -142 moneyline favorites for this matchup against the White Sox (+119). Baltimore is the favorite on the run line (-1.5 with +117 odds). The over/under is 8 runs for the matchup.

Here is everything you need from a betting perspective on the Orioles-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Toronto Blue Jays.

Orioles vs. White Sox Game Information & Odds

• When: Monday, September 15, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MASN2

Orioles vs. White Sox Prediction

• Score Prediction: White Sox 5, Orioles 4
• Total Prediction: Over 8 runs
• Win Probabilities: Orioles 52%, White Sox 48%

Orioles vs. White Sox Betting Insights

• The Orioles have won 31, or 48.4%, of the 64 games they've played as favorites this season.
• Baltimore has entered 20 games this season favored by -142 or more and is 11-9 in those contests.
• Sportsbooks have implied with the moneyline set for this matchup that the Orioles have a 58.7% chance to win.
• The White Sox have been chosen as underdogs in 148 games this year and have walked away with the win 56 times (37.8%) in those games.
• Chicago has a win-loss record of 40-74 when favored by +119 or worse by bookmakers this year.
• The moneyline set for this matchup implies the White Sox have a 45.7% chance of walking away with the win.

Orioles Recent Betting Performance

• The Orioles have been named the moneyline favorite by bookmakers just twice in the last 10 games, and won both matchups.
• In their last 10 outings -- all had a set run total -- the Orioles and their opponents combined to hit the over on the total three times.
• The Orioles' ATS record is 5-5-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson comes into Monday's game hitting .271 with 62 RBI, both team-leading marks for the Orioles. He has also launched 16 home runs in 2025.
• Among all hitters in baseball, Henderson's home run total ranks him 112th, and his RBI tally ranks him 97th.
• Henderson has collected a hit in two games in a row. In his last five games he is hitting .250 with two doubles, three walks and an RBI.
• Holliday has shown off his power as he leads his team with 17 home runs.
• Of all MLB hitters, Holliday is 100th in home runs and 129th in RBI.
• Holliday has seven straight games with at least one hit. In his last 10 outings he is hitting .361 with two home runs, seven walks and four RBIs.
• Ryan Mountcastle is hitting .256 with 18 doubles, five home runs and 14 walks.
• Colton Cowser has 12 doubles, 14 home runs and 22 walks while hitting .201.

Orioles Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won five of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 5-5-0 in their last 10 games with a total.
• The White Sox have a record of 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .232 with 31 doubles, two triples, 14 home runs and 50 walks.
• In all of the big leagues, Vargas ranks 141st in homers and 138th in RBI.
• Benintendi is batting .241 with 16 doubles, two triples, 19 home runs and 37 walks.
• Benintendi is 80th among all hitters in the big leagues in home runs, and 107th in RBI.
• Lenyn Sosa leads the White Sox in long balls (20), runs batted in (68) and has a team-best batting average of .263.
• Chase Meidroth is batting .269 with 15 doubles, five home runs and 43 walks.

White Sox Team Props

Orioles vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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