Orioles vs. Nationals Prediction, Odds, Picks - May 17

Cedric Mullins and the Baltimore Orioles will attempt to knock off German Rosario and the Washington Nationals when the teams square off on Saturday at 4:05 p.m. ET. The Nationals have been listed as +127 moneyline underdogs for this matchup against the favored Orioles (-150). Baltimore (-1.5) is the favorite on the run line. The contest's total is listed at 11 runs.

Here's everything you need from a betting perspective on the Orioles-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. Orioles Highlights | MLB on FOX

Check out the best highlights between the Washington Nationals and the Baltimore Orioles.

Orioles vs. Nationals Game Information & Odds

• When: Saturday, May 17, 2025 at 4:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: Fox Sports 1, MASN, and MASN2

Orioles vs. Nationals Prediction

• Score Prediction: Orioles 8, Nationals 7
• Total Prediction: Over 11 runs
• Win Probabilities: Orioles 51%, Nationals 49%

Orioles vs. Nationals Betting Insights

• The Orioles have entered the game as favorites 26 times this season and won nine, or 34.6%, of those games.
• Baltimore has been at least -150 moneyline favorites three times this season, but were upset in all of those games.
• The Orioles have a 60% chance to win this game based on the implied probability of the moneyline.
• The Nationals have been chosen as underdogs in 38 games this year and have walked away with the win 17 times (44.7%) in those games.
• This season, Washington has come away with a win eight times in 23 chances when named as an underdog of at least +127 or longer on the moneyline.
• The Nationals have an implied victory probability of 44.1% according to the moneyline set for this matchup.

Orioles Recent Betting Performance

• The Orioles went 2-5 over the seven games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Orioles combined with their opponents to hit the over on the total four times.
• The Orioles have gone 2-8-0 against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Mullins is the Orioles best power option, connecting on eight homers this season in addition to collecting 25 RBI, both team highs.
• In all of the majors, Mullins ranks 35th in homers and 40th in RBI.
• Ryan O'Hearn has four doubles, seven home runs and 15 walks while hitting .304.
• O'Hearn heads into this game looking for his fourth game in a row with a hit. During his last five outings he is hitting .294 with four walks.
• Adley Rutschman is hitting .214 with five doubles, a triple, four home runs and 19 walks.
• Rutschman is on a two-game hitting streak entering this contest. In his last five games he is hitting .353 with a double, a triple, a walk and an RBI.
• Gunnar Henderson has eight doubles, two triples, six home runs and nine walks while hitting .259.

Orioles Team Props

Nationals Recent Betting Performance

• In nine games over the last 10 matchups when set as underdogs by bookmakers, the Nationals had a record of 3-6.
• In their last 10 games with a total, the Nationals and their opponents have combined to hit the over three times.
• Over their last 10 games, the Nationals are 4-6-0 against the spread.

Nationals Recent Stats

Nationals Player Insights

• James Wood has swatted a team-leading 12 long balls.
• Among all batters in the majors, Wood's home run total ranks seventh and his RBI tally ranks 28th.
• C.J. Abrams is hitting .305 to lead the lineup.
• Abrams ranks 70th in homers and 142nd in RBI among all hitters in MLB.
• Nathaniel Lowe has collected a team-high 31 runs batted in.
• Keibert Ruiz has six doubles, two home runs and eight walks while batting .279.

Nationals Team Props

Nationals vs. Orioles Highlights | MLB on FOX

Check out the best highlights between the Washington Nationals and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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