Orioles vs. Nationals Prediction, Odds, Picks - May 16

The Washington Nationals and C.J. Abrams take the field against Ryan Mountcastle and the Baltimore Orioles on Friday at Oriole Park at Camden Yards. The Orioles are listed as -124 moneyline favorites in this matchup against the Nationals (+105). Baltimore is a 1.5-run favorite (at +164 odds). The matchup's over/under has been listed at 9 runs.

Here's everything you need to know from a betting perspective on the Orioles-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Nationals Game Information & Odds

• When: Friday, May 16, 2025 at 7:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and MASN2

Orioles vs. Nationals Prediction

• Score Prediction: Orioles 6, Nationals 5
• Total Prediction: Over 9 runs
• Win Probabilities: Orioles 52%, Nationals 48%

Orioles vs. Nationals Betting Insights

• This season, the Orioles have been favored 25 times and won nine, or 36%, of those games.
• Baltimore has a record of 8-11 in games when oddsmakers favor them by at least -124 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Orioles have a 55.4% chance to win.
• The Nationals have been victorious in 16, or 43.2%, of the 37 contests they have been chosen as underdogs in this season.
• Washington has a mark of 13-17 in contests where bookmakers favor it by +105 or worse on the moneyline.
• The moneyline set for this matchup implies the Nationals have a 48.8% chance of walking away with the win.

Orioles Recent Betting Performance

• The Orioles were the moneyline favorite for seven of their last 10 games, and they went 2-5 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Orioles and their opponents combined to hit the over on the total five times.
• The Orioles have put together a 2-8-0 record against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• The Orioles' best power option comes in the form of Cedric Mullins and his eight-dinger 25-RBI season, both team highs.
• Among all hitters in the majors, Mullins' home run total places him 33rd, and his RBI tally puts him 37th.
• Mullins has collected a hit in two games in a row. In his last five games he is batting .263 with two doubles, a home run and four RBIs.
• Ryan O'Hearn is batting .295 with four doubles, seven home runs and 13 walks.
• O'Hearn has two straight games with at least one hit. During his last five outings he is hitting .235 with three walks.
• Gunnar Henderson leads the Orioles with a .268 batting average.
• Adley Rutschman is hitting .200 with four doubles, a triple, four home runs and 19 walks.

Orioles Team Props

Nationals Recent Betting Performance

• The Nationals have played as underdogs in nine of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Nationals and their opponents are 3-6-1 when it comes to hitting the over.
• The Nationals have a record of 4-6-0 ATS over their last 10 games.

Nationals Recent Stats

Nationals Player Insights

• James Wood paces the Nationals with 11 long balls.
• Among all hitters in the majors, Wood is eighth in homers and 37th in RBI.
• Abrams has a club-leading .317 batting average.
• Abrams ranks 67th in homers and 137th in RBI among all batters in the big leagues.
• Nathaniel Lowe leads the Nationals with 30 runs batted in.
• Keibert Ruiz has six doubles, two home runs and eight walks while hitting .285.

Nationals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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